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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025351
pages 127-138

Short-Term Effects of Titanium Dioxide Nanofiber on the Renal Function of Male Sprague Dawley Rats

Daniel A. Hunter
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Leah K. Bartel
Department of Chemistry and Physics, Warren-Wilson College, Swannanoa, NC 28778
Ian Byrd
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Bethany Bogan
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Wilson Yau
Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602
Ji Wu
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Worlanyo Eric Gato
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458

ABSTRACT

Titanium dioxide nanofiber (TDNF) is widely used in the manufacture of various household products, including cosmetics. As a result, the possibility exists for TDNFs to affect human health. Because the kidneys are responsible for filtering out waste from the blood, the goal of the present study was to investigate the short-term effects of TDNF on kidney function of male Sprague Dawley rats. To achieve study objectives, 6- to 7-wk-old male rats were exposed via oral gavage to a total of 0, 40, and 60 parts per million of TDNF for 2 wk. The TDNF was fabricated by electrospinning and then dissolved in water. We measured serum concentration of lactate dehydrogenase, renal histopathology, identification of TDNF in kidney tissue via scanning electron microscopy, and quantitative amounts of titanium-47 in kidney tissue. We also measured specific gene-expression analysis of transcripts involved in apoptosis, inflammation, cell-division regulation, cell structure, and motility. Results showed a slight dose-dependent reduction in renal weight. In contrast, a concentration-dependent elevation in titanium-47 amounts was noted in kidney tissue. We found no significant differences in histopathological patterns. Gnat3 and Hepacam3 were up-regulated in TDNF-treated groups. Up-regulation of NF-κB likely indicated the involvement of renal-tissue inflammation via an independent mechanism. Similarly, Gadd45-α was significantly overexpressed in kidney tissues. This transcript was previously increased following stressful growth-arrest conditions and treatment with DNA-damaging agents. Our overall results suggest marginal renal toxicity in Sprague Dawley rats after ingesting TDNF.


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