图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025351
pages 127-138

Short-Term Effects of Titanium Dioxide Nanofiber on the Renal Function of Male Sprague Dawley Rats

Daniel A. Hunter
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Leah K. Bartel
Department of Chemistry and Physics, Warren-Wilson College, Swannanoa, NC 28778
Ian Byrd
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Bethany Bogan
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Wilson Yau
Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602
Ji Wu
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458
Worlanyo Eric Gato
Department of Chemistry, Georgia Southern University, Statesboro, GA 30458

ABSTRACT

Titanium dioxide nanofiber (TDNF) is widely used in the manufacture of various household products, including cosmetics. As a result, the possibility exists for TDNFs to affect human health. Because the kidneys are responsible for filtering out waste from the blood, the goal of the present study was to investigate the short-term effects of TDNF on kidney function of male Sprague Dawley rats. To achieve study objectives, 6- to 7-wk-old male rats were exposed via oral gavage to a total of 0, 40, and 60 parts per million of TDNF for 2 wk. The TDNF was fabricated by electrospinning and then dissolved in water. We measured serum concentration of lactate dehydrogenase, renal histopathology, identification of TDNF in kidney tissue via scanning electron microscopy, and quantitative amounts of titanium-47 in kidney tissue. We also measured specific gene-expression analysis of transcripts involved in apoptosis, inflammation, cell-division regulation, cell structure, and motility. Results showed a slight dose-dependent reduction in renal weight. In contrast, a concentration-dependent elevation in titanium-47 amounts was noted in kidney tissue. We found no significant differences in histopathological patterns. Gnat3 and Hepacam3 were up-regulated in TDNF-treated groups. Up-regulation of NF-κB likely indicated the involvement of renal-tissue inflammation via an independent mechanism. Similarly, Gadd45-α was significantly overexpressed in kidney tissues. This transcript was previously increased following stressful growth-arrest conditions and treatment with DNA-damaging agents. Our overall results suggest marginal renal toxicity in Sprague Dawley rats after ingesting TDNF.


Articles with similar content:

Dietary Turmeric Post-Treatment Decreases DMBA-Induced Hamster Buccal Pouch Tumor Growth by Altering Cell Proliferation and Apoptosis-Related Markers
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 4
Pooja Tajpara, Gaurav Kumar, Girish Maru
Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 4
Veronica T. Dias, Valdemiro A. da Silva Junior, M.E. Burger, Geisa S. Dolci, Katiane Roversi, Camila S. Pase, Luiz André de Lima, Caren T. D. Antoniazzi, Leandro M. de Carvalho, Fernanda Lima, Hecson J. Segat, Patricia Reckziegel, Raquel C. S. Barcelos, N. Boufleur, Dalila Benvegnu, Fabiola Trevizol
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Cherupally Krishnan Krishnan Nair, Prasad Y. Lamrood, Yogesh Bharat Dalvi, Ruby Varghese
Pharmacological Investigation of Ceraceomyces tessulatus (Agaricomycetes) in Mice with Nonalcoholic Steatohepatitis
International Journal of Medicinal Mushrooms, Vol.22, 2020, issue 7
Vengadeshprabhu Karuppagounder, Remya Sreedhar, Somasundaram Arumugam, Kenichi Watanabe, Meilei Harima, Rejina Afrin, Xavier Alexander, Ravichandiran Velayutham
Protective Effects of a By-Product of the Pecan Nut Industry (Carya illinoensis) on the Toxicity Induced by Cyclophosphamide in Rats Carya illinoensis Protects Against Cyclophosphamide- Induced Toxicity
Journal of Environmental Pathology, Toxicology and Oncology, Vol.29, 2010, issue 3
R.C.S. Barcelos, M.E. Burger, N.M.B. Martins, C. Vareli, Camila S. Pase, L.G. Muller, Patricia Reckziegel, N. Boufleur, Dalila Benvegnu