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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025086
pages 103-115

In Vivo Anticancer Activity of Biosynthesized Zinc Oxide Nanoparticle using Turbinaria conoides on a Dalton's Lymphoma Ascites Mice Model

R. Khoushika Raajshree
Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India
Durairaj Brindha
Department of Biochemistry, PSG College of Arts & Science, Coimbatore, Tamil Nadu, India

ABSTRACT

In the present study, we aimed to evaluate the anticancer effect of zinc oxide nanoparticles (ZnO-NPs) synthesized from Turbinaria conoides against a murine model of Dalton's lymphoma ascites (DLA). Nanoparticles were synthesized from the hydroethanolic extract of T. conoides (HETC). An ultraviolet-visible spectrophotometric analysis was performed to confirm the formation of ZnO-NPs. Size, morphology, and elemental composition of ZnO-NPs were also analyzed using scanning electron microscopy–energy dispersive X-ray diffraction (SEM-EDX). Healthy Swiss albino mice were intraperitoneally induced with DLA cells and treated with ZnO-NPs and HETC at a dose of 50 μg/kg (p.o.). The effects of ZnO-NPs and HETC on body weight, tumor volume, hematological profile, and liver biochemical parameters were studied. The results of in vivo studies revealed that the treatment with ZnO-NPs and HETC decreased the tumor volume, thereby increasing the lifespan of DLA-bearing mice. The treatment also restored the alterations in hematological profile, antioxidant status, and activities of liver marker enzymes. These histopathological results provided the evidence for the protective effect of ZnO-NPs and HETC on DLA-induced mice. Thus, we conclude that ZnO-NPs possess more significant anticancer and antioxidant activities in DLA-bearing mice than HETC.


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