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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i4.40
pages 277-285

Analysis of Spontaneous and Streptonigrin-Induced Sister Chromatid Exchanges in Peripheral Lymphocytes of Aircrew Members of International Flights

Julieta Sanchez
Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biologia Celular (IMBICE, CCT-La Plata-CONICET-CICPBA), C.C. 403, 1900 La Plata, Argentina
Martha Susana Bianchi
Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biologia Celular (IMBICE, CCT-La Plata-CONICET-CICPBA); Miembro de la Carrera del Investigador Cientifico del CONICET, Argentina
Vicente Ruben Ciancio
Universidad Nacional de La Plata, Facultad de Ciencias Médicas, 120 y 60, 1900 La Plata, Argentina
Alejandro Daniel Bolzan
Laboratorio de Citogenética y Mutagénesis, Instituto Multidisciplinario de Biologia Celular (IMBICE, CCT-La Plata-CONICET-CICPBA); Miembro de la Carrera del Investigador Cientifico del CONICET, Argentina

ABSTRACT

In this work, we extend our previous studies concerning mutagen sensitivity in flight personnel from commercial airlines by analyzing the frequency of spontaneous and streptonigrin (SN)-induced sister chromatid exchanges (SCEs) in peripheral blood lymphocytes of 18 long-haul aircrew members from Argentina and of 18 control individuals. Statistical analysis revealed no significant differences between aircrew and controls in the background level of SCEs (p > 0.05), which suggests that chronic exposure to cosmic radiation and other occupational hazards does not affect SCEs frequency in peripheral lymphocytes of aircrews. The fact that almost no correlation was found between cumulative flight hours and the yield of spontaneous SCEs in aircrews adds further support to this assumption. Therefore, the background SCEs frequency cannot be use as a valid biomarker to determine the genotoxic effects of cosmic radiation or other occupational hazards exposure in aircrews. Following SN treatment, a significant increase in the mean frequency of SCEs was observed in the control group (p < 0.05) but not in the aircrew group (p > 0.05), suggesting that at the population level, aircrew are more resistant to the mutagenic effects of SN than controls. The reasons of this resistance remain to be determined. Since cosmic radiation had no effect on the background SCEs frequency and no relationship was found between cumulative flight hours and SCEs inducer effect by SN in aircrews, a direct effect of cosmic radiation on SN resistance should be discarded.


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