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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i4.50
pages 287-293

In Vivo Evaluation of the Toxic Effects of Pyrimethamine on Spermatogenesis in Male Mice

Nilufer Aydemir
Uludag University, Art and Science Faculty, Biology Department, Gorukle, 16059 Bursa, Turkey
Serap Celikler
Uludag University, Art and Science Faculty, Biology Department, Gorukle, 16059 Bursa, Turkey
Rahmi Bilaloglu
Uludag University, Art and Science Faculty, Biology Department, Gorukle, 16059 Bursa, Turkey

ABSTRACT

Pyrimethamine is known to have antimalarial activities and used clinically in the therapy of toxoplasmosis and human immunodeficiency virus−associated pneumonia. In this study we aimed to test the effects of pyrimethamine on spermatogenesis in mice. For this aim, animals were given pyrimethamine as a single application and the doses were 5, 10, 20, and 40 mg/kg. For the spermatogenic effects, the sperm shape abnormality, epididymal sperm counts, and testes weights were evaluated at the end of days 7, 14, 21, 28, and 35 after single pyrimethamine injection at the first day. Pyrimethamine increased the frequency of abnormal sperm shape for all studied weeks except the first week and its germ cell stage−specific effects correspond to spermatozoa, spermatids, and spermatocytes. It also decreased the epididymal sperm counts at the end of days 28 and 35, which corresponds to the spermatocyte stage of mouse spermatogenesis.


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