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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Utility of the F98 Rat Glioma Model for Photodynamic Therapy

卷 26, 册 2, 2007, pp. 149-155
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i2.100
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摘要

A syngeneic rat brain tumor model consisting of F98 glioma cells in Fischer rats was investigated for its utility in PDT studies. Results of in vitro studies demonstrated that the F98 cell line was sensitive to ALA-PDT, especially at low light irradiances. Histological examination revealed that F98 tumors share many fundamental characteristics with human GBMs, including rapid growth and infiltrative behavior. ALA-PDT in normal brain showed that high light fluencies (26 J) delivered at relatively low powers (10 mW) are capable of causing significant edema. These findings suggest that light irradiation parameters should be chosen carefully when treating tumor-bearing animals. Rats inoculated with F98 cells preincubated in ALA showed a significant survival advantage following light exposure. Taken together, the results suggest that the F98 rat glioma model is appropriate for PDT studies of malignant gliomas.

对本文的引用
  1. Nokes Brandon, Apel Matt, Jones Carol, Brown Gabrielle, Lang Julie E., Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications, Journal of Surgical Research, 181, 2, 2013. Crossref

  2. Madsen Steen J., Mathews Marlon S., Angell-Petersen Even, Sun Chung-Ho, Vo Van, Sanchez Rogelio, Hirschberg Henry, Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids, Journal of Neuro-Oncology, 91, 2, 2009. Crossref

  3. Zhang Xufeng, Cong Damin, Shen Dawei, Gao Xin, Chen Lei, Hu Shaoshan, The effect of bumetanide on photodynamic therapy-induced peri-tumor edema of C6 glioma xenografts, Lasers in Surgery and Medicine, 46, 5, 2014. Crossref

  4. Mathews Marlon S., Blickenstaff Joseph W., Shih En-Chung, Zamora Genesis, Vo Van, Sun Chung-Ho, Hirschberg Henry, Madsen Steen J., Photochemical internalization of bleomycin for glioma treatment, Journal of Biomedical Optics, 17, 5, 2012. Crossref

  5. Zhan Qi, Yue Wu, Shaoshan Hu, The inhibitory effect of photodynamic therapy and of an anti-VCAM-1 monoclonal antibody on the in vivo growth of C6 glioma xenografts, Brazilian Journal of Medical and Biological Research, 44, 5, 2011. Crossref

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