每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
Indexed in
Utility of the F98 Rat Glioma Model for Photodynamic Therapy
摘要
A syngeneic rat brain tumor model consisting of F98 glioma cells in Fischer rats was investigated for its utility in PDT studies. Results of in vitro studies demonstrated that the F98 cell line was sensitive to ALA-PDT, especially at low light irradiances. Histological examination revealed that F98 tumors share many fundamental characteristics with human GBMs, including rapid growth and infiltrative behavior. ALA-PDT in normal brain showed that high light fluencies (26 J) delivered at relatively low powers (10 mW) are capable of causing significant edema. These findings suggest that light irradiation parameters should be chosen carefully when treating tumor-bearing animals. Rats inoculated with F98 cells preincubated in ALA showed a significant survival advantage following light exposure. Taken together, the results suggest that the F98 rat glioma model is appropriate for PDT studies of malignant gliomas.
-
Nokes Brandon, Apel Matt, Jones Carol, Brown Gabrielle, Lang Julie E., Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications, Journal of Surgical Research, 181, 2, 2013. Crossref
-
Madsen Steen J., Mathews Marlon S., Angell-Petersen Even, Sun Chung-Ho, Vo Van, Sanchez Rogelio, Hirschberg Henry, Motexafin gadolinium enhances the efficacy of aminolevulinic acid mediated-photodynamic therapy in human glioma spheroids, Journal of Neuro-Oncology, 91, 2, 2009. Crossref
-
Zhang Xufeng, Cong Damin, Shen Dawei, Gao Xin, Chen Lei, Hu Shaoshan, The effect of bumetanide on photodynamic therapy-induced peri-tumor edema of C6 glioma xenografts, Lasers in Surgery and Medicine, 46, 5, 2014. Crossref
-
Mathews Marlon S., Blickenstaff Joseph W., Shih En-Chung, Zamora Genesis, Vo Van, Sun Chung-Ho, Hirschberg Henry, Madsen Steen J., Photochemical internalization of bleomycin for glioma treatment, Journal of Biomedical Optics, 17, 5, 2012. Crossref
-
Zhan Qi, Yue Wu, Shaoshan Hu, The inhibitory effect of photodynamic therapy and of an anti-VCAM-1 monoclonal antibody on the in vivo growth of C6 glioma xenografts, Brazilian Journal of Medical and Biological Research, 44, 5, 2011. Crossref