图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i2.40
pages 89-103

Biochemical Manipulation via Iron Chelation to Enhance Porphyrin Production from Porphyrin Precursors

Alison Curnow
Cornwall Dermatology Research, Peninsula Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, UK TR1 3HD
Andrew Pye
Cornwall Dermatology Research, Peninsula Medical School, Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, UK TR1 3HD

ABSTRACT

Topical protoporphyrin IX (PPIX) induced photodynamic therapy (PDT) of basal cell carcinoma (BCC) produces good clinical outcomes with excellent cosmesis as long as the disease remains superficial. Efficacy for nodular BCC, however, appears inferior to standard treatment unless repeat treatments are performed. Enhancement is therefore required and may be possible by employing iron chelating agents to temporarily increase PPIX accumulation above the levels normally obtained using aminolaevulinic acid (ALA) or the methyl ester of ALA (MAL) alone. In vitro studies investigated the efficacies of the novel iron chelator, CP94 (1,2-diethyl-3-hydroxypyridin-4-one hydrochloride), and the established iron chelator, desferrioxamine (DFO), at increasing PPIX fluorescence in cultured human lung fibroblasts and squamous carcinoma cells incubated with ALA/MAL. CP94 was found to produce greater PPIX fluorescence when administered with ALA/MAL than either congener could produce alone. CP94 was also found to be superior to DFO in the enhancement of PPIX fluorescence and could be employed to accumulate the same levels of PPIX within a shorter time period. Clinical utilization of CP94 to enhance ALA/MAL-PDT could potentially result in greater PPIX accumulation or alternatively could be employed to reduce the length of the required drug-light interval. Clinical investigation of this is currently underway.


Articles with similar content:

Preface: Special Issue of Photodynamic Therapy and Photodetection with Porphyrin Precursors for the Journal of Environmental Pathology, Toxicology, and Oncology
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Alcira Batlle, Qian Peng
Photodynamic Treatment of Oral Lesions
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Trond Warloe, Sigrid I. Kvaal
Photodynamic Effect of Curcumin on NPC/CNE2 Cells
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Naiki K. Mak, Albert W. N. Leung, H. K. Koon, Kevin K. M. Yue
Fluorescence Diagnosis and Photodynamic Therapy in Dermatology from Experimental State to Clinic Standard Methods
Journal of Environmental Pathology, Toxicology and Oncology, Vol.25, 2006, issue 1-2
Clemens Fritsch, Thomas Ruzicka
ALA and Malignant Glioma: Fluorescence-Guided Resection and Photodynamic Treatment
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 2
Tobias Beck, Jorg Ch. Tonn, Friedrich-Wilhelm Kreth, Herbert Stepp, Walter Stummer, Thomas Meinel, Thomas Pongratz