图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvPathToxOncol.v24.i2.20
pages 79-90

Inhibitory Effect(s) of Polymeric Black Tea Polyphenols on the Formation of B(a)P-Derived DNA Adducts in Mouse Skin

Rajesh Krishnan
Tobacco Carcinogenesis Group, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India
Girish Maru
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai-410210, India

ABSTRACT

The biological activities and chemopreventive properties of green tea polyphenols have been demonstrated, while similar information regarding newly formed major polymeric polyphenols in black tea are not available. Cancer chemoprevention may be achieved by the inhibition of any stage of carcinogenesis. In the present study, we investigated the anti-initiating effects of five polymeric black tea polyphenol (PBP) fractions, by determining their effects on the formation of [3H]-B(a)P-derived DNA adducts as well as the activity of cytochrome P-450 isozymes CYP 1A1 and 1A2 in vitro employing rat liver microsomes. PBP 1-3 inhibited both the microsome catalyzed [3H]-B(a)P-derived DNA adduct formation as well as the activity of CYP 1A1 and 1A2 as assessed by the decreased formation of resorufin from the respective substrates. Further investigation revealed that topical pretreatment(s) of mice with PBP 1-5 (200 μg/day × 4) resulted in a significant decrease in the levels of single topical B(a)P (1 mg/mouse) - induced DNA adducts in epidermal DNA determined by employing 32P-post labeling analysis. Overall, our results suggest that black tea-derived PBPs have one of the chemopreventive properties shown by monomeric green tea polyphenols.


Articles with similar content:

Effects of Turmeric on the Activities of Benzo (a) pyrene-Induced Cytochrome P-450 Isozymes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 1
Rachana Thapliyal, Shailesh S. Deshpande, Girish Maru
Guilandina bonduc L. Possesses Antioxidant Activity and Precludes Ferric Nitrilotriacetate (Fe-NTA) Induced Renal Toxicity and Tumor Promotion Response
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 2
Gurpreet Kaur, Irshad A. Lone, Mohammad Athar, Sarwar M. Alam
Dietary Curcumin Enhances Benzo(a)pyrene-Induced Apoptosis Resulting in a Decrease in BPDE-DNA Adducts in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 2
Rachana Garg, Girish Maru
Mitigating Acetaminophen-Induced Hepatotoxicity by Using a Water-Alcohol Extract of Phellinus caryophylli (Agaricomycetes) in a Murine Model
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 4
Cherupally Krishnan Krishnan Nair, Prasad Y. Lamrood, Yogesh Bharat Dalvi, Ruby Varghese
Broad-Spectrum Anti-Cancer Activity of O2-Arylated Diazeniumdiolates
Forum on Immunopathological Diseases and Therapeutics, Vol.1, 2010, issue 3
Larry K. Keefer