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环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Naringenin Ameliorates Doxorubicin Toxicity and Hypoxic Condition in Dalton's Lymphoma Ascites Tumor Mouse Model: Evidence from Electron Paramagnetic Resonance Imaging

卷 35, 册 3, 2016, pp. 249-262
DOI: 10.1615/JEnvironPatholToxicolOncol.2016013997
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摘要

Doxorubicin (DOX) is a well-known cytotoxic agent used extensively as a chemotherapeutic drug to eradicate a wide variety of human cancers. Reactive oxygen species (ROS)-mediated oxidative stress during DOX treatment can induce cardiac, renal, and hepatic toxicities, which can constrain its use as a potential cytotoxic agent. The present work investigates the antioxidant potential of naringenin (NAR) against DOXinduced toxicities of a Dalton's lymphoma ascites (DLA) tumor-bearing mouse model. Mice were randomized into four groups: a negative control, positive control, DOX (2.5 mg/kg) treated, and DOX (2.5 mg/kg) + NAR (50 mg/kg/d) treated. DOX administration significantly altered the levels of functional markers in blood and antioxidant enzymes in kidney, heart, lung, liver, spleen, and tumor tissues. These changes in antioxidant enzymes and successive lipid peroxidation were prevented by NAR supplementation, resulting in decreases in the risk of toxicity due to DOX therapy. Histopathology results and electron paramagnetic resonance imaging (EPRI) of the tumor microenvironment confirmed this evidence. Using EPRI, pharmacokinetics of the nitroxide, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (3-CP) was monitored intratumorally before and after chemotherapy. EPRI of the DOX + NAR–treated mouse model showed reduced tumor size with significant modification of the hypoxic condition inside the tumor microenvironment. Consequently, these findings suggest that NAR treatment significantly reduces DOX-induced toxicity and the hypoxic condition in a DLA tumor-bearing mouse model.

对本文的引用
  1. Shibu Marthandam Asokan, Agrawal Dinesh Chandra, Huang Chih-Yang, Mushrooms: A Pandora Box of Cardioprotective Phytochemicals, in Medicinal Plants and Fungi: Recent Advances in Research and Development, 4, 2017. Crossref

  2. Karim Naymul, Jia Zhenquan, Zheng Xiaodong, Cui Sunliang, Chen Wei, A recent review of citrus flavanone naringenin on metabolic diseases and its potential sources for high yield-production, Trends in Food Science & Technology, 79, 2018. Crossref

  3. Naraki Karim, Rezaee Ramin, Karimi Gholamreza, A review on the protective effects of naringenin against natural and chemical toxic agents, Phytotherapy Research, 35, 8, 2021. Crossref

  4. Masuelli Laura, Benvenuto Monica, Focaccetti Chiara, Ciuffa Sara, Fazi Sara, Bei Arianna, Miele Martino Tony, Piredda Lucia, Manzari Vittorio, Modesti Andrea, Bei Roberto, Targeting the tumor immune microenvironment with “nutraceuticals”: From bench to clinical trials, Pharmacology & Therapeutics, 219, 2021. Crossref

  5. Navarro-Hortal María D., Varela-López Alfonso, Romero-Márquez José M., Rivas-García Lorenzo, Speranza Lorenza, Battino Maurizio, Quiles José L., Role of flavonoids against adriamycin toxicity, Food and Chemical Toxicology, 146, 2020. Crossref

  6. Utkusavas Ayfer, Gurel Gurevin Ebru, Yilmazer Nadim, Uvez Ayca, Oztay Fusun, Bulut Huri, Ustunova Savas, Esener Osman B. Burak, Sonmez Kivilcim, Erol Kutucu Deniz, Meral Ismail, Dimas Konstantinos, Armutak Elif Ilkay, Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma, Biotechnic & Histochemistry, 2022. Crossref

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