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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2013008305
pages 329-341

Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis

Dalila Benvegnu
Universidade Federal da Fronteira Sul
Raquel C. S. Barcelos
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Katiane Roversi
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
N. Boufleur
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Camila S. Pase
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Fabiola Trevizol
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Hecson J. Segat
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Veronica T. Dias
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Geisa S. Dolci
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Caren T. D. Antoniazzi
Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Patricia Reckziegel
Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil
Fernanda Lima
Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Luiz André de Lima
Universidade Federal Rural de Pernambuco
Leandro M. de Carvalho
Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil
Valdemiro A. da Silva Junior
Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Pernambuco, Brazil
M.E. Burger
Programa de pós Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil

ABSTRACT

This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.


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