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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvPathToxOncol.v23.i4.70
4 pages

Urinary Excretion of Nickel After Dermal Application of Nigerian Light Crude Oil

Ibiba F. Oruambo
Department of Chemistry, Rivers State University of Science and Technology, Nkpolu, Port Harcourt, Rivers State, Nigeria

ABSTRACT

We examined the pattern of excretion of crude oil nickel (CON) in urine and feces. Adult male guinea pigs were treated with a single dose of 5mL/kg b.w. Nigerian Bonny light crude oil applied on the skin. Untreated guinea pigs served as controls. The CON content was measured spectrophotometrically by the dimethylglyoxime reaction following nitric acid:perchloric acid: sulfuric acid (3:1:1) digestion of blood, urine, and feces samples at 2, 4, 8, and 16 days after the crude oil application. We found a peak of CON excretion in the urine at 2 days and a return to the control level at 16 days. There was no change in the CON content in the feces during the observation time. We found a peak of CON content in the blood at 8 days and a return to control values at 16 days. The implication of these excretion and transport patterns of CON is discussed vis-a-vis the potential application of the urinary nickel content as a valid biochemical indicator of human exposure to environmentally spilled crude oil.


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