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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvPathToxOncol.v23.i4.60
6 pages

Mutagenic Potential of Mancozeb in Salmonella typhimurium

Yogeshwer Shukla
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India
Pankaj Taneja
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
Annu Arora
Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,Lucknow, India
Neeraj Sinha
Division of Toxicology, Central Drug Research Institute, Lucknow, India

ABSTRACT

Mancozeb, a dithiocarbamate fungicide, was examined for its possible mutagenic activity using Salmonella typhimurium tester strains TA97a, TA98, TA100, and TA102. We found that Mancozeb exhibited toxic effects at the dose of 40 μg/plate and higher with all tester strains. Mancozeb showed dose-dependent increases in the number of revertants with and without metabolic activation when it was dissolved in DMSO or acetone with strain TA97a; however, the number of revertants at the highest dose was less than two-fold compared to control values. We postulate that the true mutagenic potential of Mancozeb may be masked by its toxic effect to the tester strain used.


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