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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Low-Magnitude, High-Frequency Vibration Promotes Osteogenic Differentiation via Intensifying miRNA-335-5p Expression

卷 38, 册 3, 2019, pp. 271-283
DOI: 10.1615/JEnvironPatholToxicolOncol.2019030625
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摘要

Certain mechanical stimuli−particularly low-magnitude, high-frequency vibration−could induce bone marrow stem cell osteogenic differentiation and promote bone formation via Wnt signaling pathway, although the molecular mechanism is still unclear. In this study, we found that miR-335-5p is significantly upregulated after low-magnitude, high-frequency vibration, which suppresses the expression of the Wnt signaling inhibitor Dickkopf-related protein 1. Inhibition of miR-335-5p greatly reduced the osteogenic differentiation. Furthermore, the increase of miR-335-5p level was also confirmed in vivo after LMHF vibration in rabbit. Our study elucidates the prominent role of miRNAs that links the LMHF vibration and osteogenic differentiation.

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对本文的引用
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  2. Mao Liwei, Guo Jianmin, Hu Linghui, Li Lexuan, Xu Jiake, Zou Jun, The effects of biophysical stimulation on osteogenic differentiation and the mechanisms from ncRNAs , Cell Biochemistry and Function, 39, 6, 2021. Crossref

  3. Sun Yuyang, Wan Ben, Wang Renxian, Zhang Bowen, Luo Peng, Wang Diaodiao, Nie Jing-Jun, Chen Dafu, Wu Xinbao, Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

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