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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Effect of Ukrain on Cell Survival and Apoptosis in the Androgen-Independent Prostate Cancer Cell Line PC-3

卷 30, 册 1, 2011, pp. 11-19
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i1.20
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摘要

Prostate cancer is the most common malignancy and second leading cause of cancer death in male population in all developing countries. Ukrain is a reaction product of different alkaloids from Chelidonium majus L. (celandine) conjugated with thiophosphoric acid. It has cytotoxic effects on various malignant cells. Cell viability was assessed by MTT method in PC-3 cells after the treatment of Ukrain. The IC50 value was observed in 10 μg concentration of Ukrain. Bax, Bad and FasL mRNA expressions were analysed by RT-PCR and protein expressions of p- Akt, Bcl-2 and caspase 10 were analysed by western blot method. Nuclear staining was detected by DAPI staining. Ukrain significantly increased the proapoptotic mRNA expressions of Bad, Bax and FasL. Ukrain decreased the cell survival protein p-Akt and also antiapoptotic protein Bcl-2. Ukrain increased the protein levels of cleaved PARP and caspases-10. This study suggests that Ukrain decreases the cell survival of androgen independent prostate cancer cells and induces apoptosis, which highlights the importance of Ukrain as a therapeutic drug for the androgen independent prostate cancer treatment.

对本文的引用
  1. Skivka L. M., Fedorchuk O. G., Rudyk M. P., Pozur V. V., Khranovska N. M., Grom M. Yu., Nowicky J. W., Antineoplastic drug NSC631570 modulates functions of hypoxic macrophages, Cytology and Genetics, 47, 5, 2013. Crossref

  2. Wang Ning, Tan Hor-Yue, Li Lei, Yuen Man-Fung, Feng Yibin, Berberine and Coptidis Rhizoma as potential anticancer agents: Recent updates and future perspectives, Journal of Ethnopharmacology, 176, 2015. Crossref

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