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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2014011859
pages 349-361

Antioxidative Effects of Schidandrin B and Green Tea Polyphenols Against Mercuric Chloride-Induced Hepatotoxicity in rats

Yu Deng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Zhaofa Xu
Department of Environmental Health, School of Public Health, China Medical University
Bin Xu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Wei Liu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Shu Feng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Tianyao Yang
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001

ABSTRACT

In the present study, we investigated the hepatoprotective effects of schisandrin B (Sch B) and green tea polyphenols (GrTP), two natural antioxidants, against Hg hepatotoxicity. Fifty-six rats were randomly divided into four groups of fourteen animals in each group: control group, Hg-treated group, Sch B pretreated group, and GrTP pretreated group. HgCl2 injection increased Hg accumulation, pathological and ultrastructural injury, lactate dehydrogenase (LDH) level, alanine transaminase (ALT) level, apoptosis, reactive oxygen species (ROS) level, glutathione (GSH) level, and malondialdehyde (MDA) level. HgCl2 injection decreased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. Sch B and GrTP protected against Hg-induced dysfunction and liver injury by enhancing the antioxidant defense system. Our results indicate that Sch B and GrTP exert antioxidative effects against Hg-induced hepatotoxicity in rats.