每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
Indexed in
Attenuation of Lead-Induced Oxidative Stress in Rat Brain, Liver, Kidney and Blood of Male Wistar Rats by Moringa Oleifera Seed Powder
摘要
Moringa oleifera is a tree belonging to Moringaceae family and its leaves and seeds are reported to have ameliorative effects against metal toxicity. In the present investigation, M. oleifera seed powder was tested against lead-induced oxidative stress and compared against meso-2, 3-dimercaptosuccinic acid (DMSA) treatment. Male Wistar rats (100−120 g) were divided into four groups: control (2000 ppm of sodium acetate for 2 weeks), exposed (2000 ppm of lead acetate for 2 weeks), Moringa treated (500 mg/kg for 7 days after lead exposure), and DMSA treated (90 mg/kg for 7 days after lead exposure). After exposure and treatment periods, rats were sacrificed and the brain was separated into cerebellum, hippocampus, frontal cortex, and brain stem; liver, kidney, and blood were also collected. The data indicated a significant (p<0.05) increase in reactive oxygen species (ROS), lipid perioxidation products (LPP), total protein carbonyl content (TPCC), and metal content of brain regions, liver, and kidney in the exposed group compared with their respective controls. In the blood, delta-amino levulinic acid dehydratase (ALAD) activity, RBC, WBC, hemoglobin, and hematocrit showed significant (p<0.05) decrease on lead exposure. However, administration of M. oleifera restored all the parameters back to control, tissue-specifically, and also showed improvement in restoration better than DMSA treatment, indicating reduction of the negative effects of lead-induced oxidative stress.
-
Ghasemi Simagol, Hosseini Mahmoud, Feizpour Azadeh, Alipour Fatemeh, Sadeghi Akram, Vafaee Farzaneh, Mohammadpour Toktam, Soukhtanloo Mohammad, Ebrahimzadeh Bideskan Alireza, Beheshti Farimah, Beneficial effects of garlic on learning and memory deficits and brain tissue damages induced by lead exposure during juvenile rat growth is comparable to the effect of ascorbic acid, Drug and Chemical Toxicology, 40, 2, 2017. Crossref
-
Assi Mohammed Abdulrazzaq, Hezmee Mohd Noor Mohd, Haron Abd Wahid, Sabri Mohd Yusof, Rajion Mohd Ali, The detrimental effects of lead on human and animal health, Veterinary World, 9, 6, 2016. Crossref
-
Kim Kyoung-Nam, Kwon Ho-Jang, Hong Yun-Chul, Low-level lead exposure and autistic behaviors in school-age children, NeuroToxicology, 53, 2016. Crossref
-
Abarikwu Sunny O., Benjamin Sussan, Ebah Sunday Godspower, Obilor Godbless, Agbam Goodluck, Protective effect of Moringa oleifera oil against HgCl2-induced hepato- and nephro-toxicity in rats, Journal of Basic and Clinical Physiology and Pharmacology, 28, 4, 2017. Crossref
-
Nan Aruo, Jia Yangyang, Li Xin, Liu Meiling, Zhang Nan, Chen Lijian, Yang Ti, Xu Yiqin, Dai Xin, Cheng Ying, Liu Zhenzhong, Ling Yihui, Jiang Yiguo, Editor’s Highlight: lncRNAL20992 Regulates Apoptotic Proteins to Promote Lead-Induced Neuronal Apoptosis, Toxicological Sciences, 161, 1, 2018. Crossref
-
Noureen Aasma, Jabeen Farhat, Tabish Tanveer A, Zahoor Muhammad Kashif, Ali Muhammad, Iqbal Rehana, Yaqub Sajid, Chaudhry Abdul Shakoor, Ameliorative effects of Moringa oleifera on copper nanoparticle induced toxicity in Cyprinus carpio assessed by histology and oxidative stress markers, Nanotechnology, 29, 46, 2018. Crossref
-
Wu Yue, Baylin Ana, Colacino Justin A, Iron, Oxidative Stress, and Δ9 Stearoyl-CoenzymeA Desaturase Index (C16:1/C16:0): An Analysis Applying the National Health and Nutrition Examination Survey 2003–04, Current Developments in Nutrition, 2, 1, 2018. Crossref
-
Idoga Enokela Shaibu, Ambali Suleiman Folorunsho, Ayo Joseph Olusegun, Mohammed Aliyu, Assessment of antioxidant and neuroprotective activities of methanol extract of Moringa oleifera Lam. leaves in subchronic chlorpyrifos-intoxicated rats, Comparative Clinical Pathology, 27, 4, 2018. Crossref
-
Mabrouk Aymen, Thymoquinone attenuates lead‐induced nephropathy in rats, Journal of Biochemical and Molecular Toxicology, 33, 1, 2019. Crossref
-
Jana Suryashis, Chattopadhyay Sandip, Dey Arindam, Perveen Hasina, Dolai Durgapada, Involvement of metallothionein, homocysteine and B-vitamins in the attenuation of arsenic-induced uterine disorders in response to the oral application of hydro-ethanolic extract ofMoringa oleiferaseed: a preliminary study, Drug and Chemical Toxicology, 43, 1, 2020. Crossref
-
Wu Chih-Yin, Wong Chung-Shun, Chung Chi-Jung, Wu Mei-Yi, Huang Ya-Li, Ao Pui-Lam, Lin Yuh-Feng, Lin Ying-Chin, Shiue Horng-Sheng, Su Chien-Tien, Chen Hsi-Hsien, Hsueh Yu-Mei, The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population, Journal of Hazardous Materials, 375, 2019. Crossref
-
Abdel-Daim Mohamed M., Alkahtani Saad, Almeer Rafa, Albasher Gadah, Alleviation of lead acetate-induced nephrotoxicity by Moringa oleifera extract in rats: highlighting the antioxidant, anti-inflammatory, and anti-apoptotic activities, Environmental Science and Pollution Research, 27, 27, 2020. Crossref
-
Abdel-Daim Mohamed M., Khalil Samah R., Awad Ashraf, Abu Zeid Ehsan H., El-Aziz Reda Abd, El-Serehy Hamed A., Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats, Nutrients, 12, 4, 2020. Crossref
-
Ghimire Saurav, Subedi Lalita, Acharya Namrata, Gaire Bhakta Prasad, Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases, Journal of Agricultural and Food Chemistry, 69, 48, 2021. Crossref
-
Yuan Yan, Zhao Shi Wen, Wen Shuang Quan, Zhu Qiao Ping, Wang Li, Zou Hui, Gu Jian Hong, Liu Xue Zhong, Bian Jian Chun, Liu Zong Ping, Alpha-Lipoic Acid Attenuates Cadmium- and Lead-Induced Neurotoxicity by Inhibiting Both Endoplasmic-Reticulum Stress and Activation of Fas/FasL and Mitochondrial Apoptotic Pathways in Rat Cerebral Cortex, Neurotoxicity Research, 39, 4, 2021. Crossref
-
Khalil Samah R., El Bohi Khlood M., Khater Safaa, Abd El-fattah Amir H., Mahmoud Fagr A., Farag Mayada R., Moringa oleifera leaves ethanolic extract influences DNA damage signaling pathways to protect liver tissue from cobalt -triggered apoptosis in rats, Ecotoxicology and Environmental Safety, 200, 2020. Crossref
-
Akter Tanzina, Rahman Md Atikur, Moni Akhi, Apu Md. Aminul Islam, Fariha Atqiya, Hannan Md. Abdul, Uddin Md Jamal, Prospects for Protective Potential of Moringa oleifera against Kidney Diseases, Plants, 10, 12, 2021. Crossref
-
Amadi Cecilia N., Orish Chinna N., Frazzoli Chiara, Orisakwe Orish E., Association of autism with toxic metals: A systematic review of case-control studies, Pharmacology Biochemistry and Behavior, 212, 2022. Crossref
-
Suleman Zubair, Engwa Godwill A., Shauli Mathulo, Musarurwa Hannibal T., Katuruza Ndinashe A., Sewani-Rusike Constance R., Neuroprotective effects of Lippia javanica (Burm.F.) Spreng. Herbal tea infusion on Lead-induced oxidative brain damage in Wistar rats, BMC Complementary Medicine and Therapies, 22, 1, 2022. Crossref
-
Wen Ying, Liu Yanyang, Huang Qi, Liu Rong, Liu Jing, Zhang Fengyu, Liu Shao, Jiang Yueping, Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway, Phytomedicine, 95, 2022. Crossref
-
Tyler Sheena E. B., Tyler Luke D. K., Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease, Natural Products and Bioprospecting, 12, 1, 2022. Crossref
-
Usman Abubakar, Kawu Mohammed Umaru, Shittu Muftau, Saleh Ahmadu, Jolayemi Kelvin Olutimilehin, Ibrahim Nuraddeen Bello, Oyetunde Joshua Seyi, Okoronkwo Magdalene Ogbonneya, Comparative effects of methanol leaf extract of Moringa oleifera and ascorbic acid on haematological and histopathological changes induced by subchronic lead toxicity in male wistar rats, Pharmacological Research - Modern Chinese Medicine, 2, 2022. Crossref