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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Radiation-Induced Incidence of Thymic Lymphoma in Mice and Its Prevention by Antioxidants

卷 26, 册 4, 2007, pp. 273-279
DOI: 10.1615/JEnvironPatholToxicolOncol.v26.i4.40
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摘要

Previous reports from our laboratory have shown that in Swiss female mice exposed to an acute dose (3 Gy) of whole body irradiation (WBI), induced thymic lymphoma (TL) resulted after three to four weeks of exposure. The present study was aimed to further evaluate dependency on gender and effect of age of mice at the time of irradiation on TL incidence. A significant decrease in body weight gain was observed in female mice exposed to WBI, which was found to be correlated with the increase in weight and size of thymus, compared to their respective controls. An increase in TL incidence was observed with the increased postirradiation time, which was 47, 80, and 93% after 90, 120, and 150 days of WBI, respectively, in female mice. In irradiated female mice, the TL incidence was significantly higher and the growth of tumor in terms of weight and size was more aggressive than in males of the same age. Moreover, mice with higher age groups at the time of irradiation showed substantial decrease in TL incidence and its aggressiveness; and these effects were more conspicuous in males than in females. In mice irradiated at the age group of three to four weeks, the TL incidence was 83 and 72% in female and male, respectively, which was decreased to 74% in female and 14% in male in the age group of 12−13 weeks. It was further observed that the postirradiation feeding of animals with antioxidants resulted in a significant decrease in TL incidence, and the prevention in TL incidence was more in animals fed with curcumin (55%) than with ascorbic acid and eugenol (20%). These results have provided significant new findings on the phenomenon of radiation-induced TL incidence related to gender and age at the time of irradiation and its prevention by postirradiation antioxidant feeding to mice.

对本文的引用
  1. Oliai Caspian, Yang Li-Xi, Radioprotectants to reduce the risk of radiation-induced carcinogenesis, International Journal of Radiation Biology, 90, 3, 2014. Crossref

  2. Pandey Badri N., Kumar Amit, Tiwari Prabha, Mishra Kaushala P., Radiobiological basis in management of accidental radiation exposure, International Journal of Radiation Biology, 86, 8, 2010. Crossref

  3. Ali Elham H.A., Arafa Nadia M.S., Comparative protective action of curcumin, memantine and diclofenac against scopolamine-induced memory dysfunction, Fitoterapia, 82, 4, 2011. Crossref

  4. Bespalov Vladimir G., Alexandrov Valery A., Semenov Alexandr L., Kovan’ko Elena G., Ivanov Sergey D., Vysochina Galina I., Kostikova Vera A., Baranenko Denis A., The inhibitory effect of meadowsweet (Filipendula ulmaria) on radiation-induced carcinogenesis in rats, International Journal of Radiation Biology, 93, 4, 2017. Crossref

  5. Jayakumar S., Bhilwade Hari N., Dange Pramod S., Sarma Haladhar D., Chaubey Ramesh C., Pandey Badri N., Magnitude of radiation-induced DNA damage in peripheral blood leukocytes and its correlation with aggressiveness of thymic lymphoma in Swiss mice, International Journal of Radiation Biology, 87, 11, 2011. Crossref

  6. Imaoka Tatsuhiko, Ishii Nobuyoshi, Kawaguchi Isao, Homma-Takeda Shino, Doi Kazutaka, Daino Kazuhiro, Nakanishi Ikuo, Tagami Keiko, Kokubo Toshiaki, Morioka Takamitsu, Hosoki Ayaka, Takabatake Masaru, Yoshinaga Shinji, Biological measures to minimize the risk of radiotherapy-associated second cancer: A research perspective, International Journal of Radiation Biology, 92, 6, 2016. Crossref

  7. Zhao Hainan, Cheng Ying, Dong Suhe, Du Jicong, Gao Fu, Sun Ding, Cui Jianguo, Ni Jin, Cai Jianming, Down regulation of miR-143 promotes radiation – Induced thymic lymphoma by targeting B7H1, Toxicology Letters, 280, 2017. Crossref

  8. Aggarwal Bharat B., Van Kuiken Michelle E., Iyer Laxmi H., Harikumar Kuzhuvelil B., Sung Bokyung, Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis, Experimental Biology and Medicine, 234, 8, 2009. Crossref

  9. Nakamura Nori, Reexamining the role of tissue inflammation in radiation carcinogenesis: a hypothesis to explain an earlier onset of cancer, International Journal of Radiation Biology, 97, 10, 2021. Crossref

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