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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2018027666
pages 351-364

Evaluation of Anti-Nociceptive and Anti-Inflammatory Effect of Luteolin in Mice

Xiaoying Fan
Department of Anesthesia, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Kexin Du
Department of Anesthesia, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Na Li
Department of Nutrition, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Zhonglei Zheng
Department of Anesthesia, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Yan Qin
Department of Anesthesia, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Jing Liu
Department of Outpatient, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China
Rong Sun
Department of Emergency, Xi'an Gaoxin Hospital, Xi'an, Shaanxi, 710075, China
Yuqiang Su
Department of Anesthesia, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710038, China

ABSTRACT

Flavonoids are polyphenolic compounds that not only impart coloration to plants and fruits, but also protect plants from pathogens, radiation, etc. They serve as a nutrient to plants and possess immense anti-oxidant properties. Research has shown that they exhibit anti-inflammatory, anti-cancer, and neuroprotective properties in both in vitro and in vivo analyses. Luteolin is one such flavonoid belongs to the group of flavones present in herbs such as thyme, chamomile, celery, and green pepper. The epidemiological data on luteolin consumption show that luteolin has anti-inflammatory activity and protects from diseases associated with inflammation. The present study assessed the anti-nociceptive properties of luteolin, a potent anti-inflammatory agent, in mice. The results demonstrated that luteolin produces a significant and dose-dependent increase in hot plate latency and tail withdrawal time. It also reduced the number of abdominal constrictions and paw licking induced by acetic acid and glutamate, respectively. Luteolin inhibited the nociceptive responses in both phases of formalin test. The anti-inflammatory property of luteolin was also confirmed with different anti-inflammatory mice models induced by carrageenan and air pouch. Behavioral changes in luteolin-treated mice were assessed with open-field test to confirm the muscle relaxant property. The results of the current study from various pain and inflammatory models confirms that luteolin possess potent anti-nociceptive and anti-inflammatory properties and can thus be used as a drug in pain management.


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