图书馆订阅: Guest
环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Antiarthritic Activity of Diallyl Disulfide against Freund’s Adjuvant–Induced Arthritic Rat Model

卷 37, 册 4, 2018, pp. 291-303
DOI: 10.1615/JEnvironPatholToxicolOncol.2018027078
Get accessGet access

摘要

Diallyl disulfide (DADS) is an organosulfur compound derived mainly from garlic and genus Allium plants, which possess diverse biological properties. The aim of the present study was to evaluate the antiarthritic activity of DADS in rats with arthritis induced using complete Freund's adjuvant (CFA). DADS (20 mg/kg and 50 mg/kg) was administered and tested against CFA-induced arthritic rats by assessing various parameters: body weight, paw volume, arthritic score, organ indices (spleen and thymus), hematological and biochemical parameters, and proinflammatory cytokines. Histopathological analyses were also performed. The treatment of rats with DADS provoked significant reductions in paw volume, edema formation, arthritic score, and organ indices, together with significant improvement in body weight. DADS treatment also improved joint destruction and reduced inflammation, which was supported by histopathological studies. DADS significantly reduced the white blood cell count and improved red blood cell count in CFA-induced rats. The anti-arthritic activity in the CFA-induced rats was further confirmed by biochemical analysis. These findings suggest that DADS prevented cartilage destruction, improved health status, and reduced inflammation by decreasing the expression of proinflammatory cytokines in arthritis-induced rats. Hence, DADS may be a potential therapeutic candidate for the treatment of rheumatoid arthritis.

对本文的引用
  1. Zhang Hongxing, Shang Chi, Tian Zhao, Amin Hatem K., Kassab Rami B., Abdel Moneim Ahmed E., Zhang Yingang, Diallyl Disulfide Suppresses Inflammatory and Oxidative Machineries following Carrageenan Injection-Induced Paw Edema in Mice, Mediators of Inflammation, 2020, 2020. Crossref

  2. Sunzini Flavia, De Stefano Susanna, Chimenti Maria Sole, Melino Sonia, Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases, International Journal of Molecular Sciences, 21, 4, 2020. Crossref

  3. Chen Guifang, Song Yuxiu, Ma Fang, Ma Yuxia, Anti-arthritic activity of D-carvone against complete Freund’s adjuvant-induced arthritis in rats through modulation of inflammatory cytokines, The Korean Journal of Physiology & Pharmacology, 24, 6, 2020. Crossref

  4. Dilek Nahzli, Papapetropoulos Andreas, Toliver-Kinsky Tracy, Szabo Csaba, Hydrogen sulfide: An endogenous regulator of the immune system, Pharmacological Research, 161, 2020. Crossref

  5. Yuan Tangbo, Wang Xiaoxu, Cai Dawei, Liao Maling, Liu Ruiping, Qin Jian, Anti-arthritic and cartilage damage prevention via regulation of Nrf2/HO-1 signaling by glabridin on osteoarthritis, Arabian Journal of Chemistry, 14, 7, 2021. Crossref

  6. Song Xiuxiu, Yue Ziqi, Nie Lulingxiao, Zhao Pengfei, Zhu Kangjian, Wang Qi, Durazzo Alessandra, Biological Functions of Diallyl Disulfide, a Garlic-Derived Natural Organic Sulfur Compound, Evidence-Based Complementary and Alternative Medicine, 2021, 2021. Crossref

  7. Li M., Mao Jian-Chun, Zhu Yi-Zhun, Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis, in Advances in Hydrogen Sulfide Biology, 1315, 2021. Crossref

  8. Malla RamaRao, Marni Rakshmitha, Chakraborty Anindita, Kamal Mohammad Amjad, Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer, Journal of Pharmaceutical Analysis, 12, 2, 2022. Crossref

  9. Arunsi Uche O, Chioma Ogbuka E, Etusim Paschal E, Owumi Solomon E, Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis, Experimental Biology and Medicine, 247, 13, 2022. Crossref

  10. Guleria Aastha, Kamboj Akhil, Kaushal Jyotsana, Anupam Kumari, Bhatnagar Archana, A Molecular Insight into Significance of Functional Foods in Better Management of Rheumatoid Arthritis, Revista Brasileira de Farmacognosia, 32, 4, 2022. Crossref

4432 文章浏览量 32 文章下载 统计数据
4432 文章浏览量 32 下载次数 10 Crossref 引用次数 Google
Scholar
引用次数

相似内容的文章:

Hepatoprotective Effects of Aqueous Extract from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Higher Basidiomycetes) on α-Amanitin−Induced Liver Injury in Mice International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 4
Jinsong Hu, Xin Wu, Jun Zeng, Qiong Liao, Zuohong Chen, Rong Zhou, Ping Zhang
The Effect of Coenzyme Q10 on Blood Ascorbic Acid, Vitamin E, and Lipid Peroxide in Chronic Cadmium Intoxication Journal of Environmental Pathology, Toxicology and Oncology, Vol.20, 2001, issue 2
Sladjan Z. Pavlovic, Vojislav M. Petrovic, Radoslav V. Zikic, Branka I. Ognjanovic, Andras S. Stajn, Zorica S. Saicic
Evaluation of Antiarthritic Effect of Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus cv. Florida (Agaricomycetes) on Complete Freund's Adjuvant Induced Arthritis in Rats International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 11
Ankita Tiwari, Anupam Jaiswal, Abhishek Shrivastava, Ayushi Chourasia, Aditya Ganeshpurkar, Nazneen Dubey
Malvidin Abrogates Oxidative Stress and Inflammatory Mediators to Inhibit Solid and Ascitic Tumor Development in Mice Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 3
Durairaj Brindha, Krishnamoorthy Kokilavani, Chinnadurai Kathirvelan, KM Sakthivel
Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 1
Smita Singh, Ekta Meghnani, Preeti Srivastava, Rashmi Sisodia, chaturbhuj Mundotiya
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain