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环境病理学,毒理学和肿瘤学期刊

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ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Colono-protective Potentiality of Methanolic Bark Extract of Acacia catechu: A Medicinal Plant against 1,2-Dimethylhydrazine–Induced Toxicity in Wistar Rats

卷 37, 册 4, 2018, pp. 273-289
DOI: 10.1615/JEnvironPatholToxicolOncol.2018026923
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摘要

The protective efficacy of methanolic bark extract of Acacia catechu Willd. (MEBA) against 1,2-dimethylhydrazine (DMH)–induced colon toxicity was investigated. Acacia catechu is considered one of the most potent medicines for various diseases in Ayurveda, a traditional system of Indian medicine. It is a widely used herb that contains a variety of bioactive components such as phenolic acids, alkaloids, and flavonoids among others. In the present study, MEBA was used as a pretreatment orally at two doses (250 and 500 mg/kg body weight [b.w.] once daily for 7 days), and DMH was administered (at a dose of 40 mg/kg b.w.) subcutaneously on day 7 in Wistar rats. The protective potential of MEBA was assessed in terms of the activity of antioxidant enzymes, lipid peroxidation, and expression of inflammatory markers (iNOS, COX-2, NF-κB, IL-6). Pretreatment with MEBA significantly abrogated oxidative damage by diminishing tissue lipid peroxidation, increasing enzymatic activities of various antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, reduced glutathione), and diminishing the induced expression of inflammatory markers in the colon tissue of Wistar rats. Furthermore, histopathological findings revealed that pretreatment with (MEBA) reduced intense filtration of inflammatory cells and significantly restored the architecture of colonic tissue. The results of this study indicate that MEBA significantly suppresses DMH-induced toxicity by ameliorating oxidative stress and inflammation and by restoring the architecture of colon tissue.

对本文的引用
  1. Islam Johirul, Shree Alpa, Afzal Shekh M., Vafa Abul, Sultana Sarwat, Protective effect of Diosmin against benzo(a)pyrene‐induced lung injury in Swiss Albino Mice, Environmental Toxicology, 35, 7, 2020. Crossref

  2. Shree Alpa, Islam Johirul, Vafa Abul, Mohammad Afzal Sheikh, Sultana Sarwat, Gallic acid prevents 1, 2‐Dimethylhydrazine induced colon inflammation, toxicity, mucin depletion, and goblet cell disintegration, Environmental Toxicology, 35, 6, 2020. Crossref

  3. Shree Alpa, Islam Johirul, Sultana Sarwat, Quercetin ameliorates reactive oxygen species generation, inflammation, mucus depletion, goblet disintegration, and tumor multiplicity in colon cancer: Probable role of adenomatous polyposis coli, β‐catenin , Phytotherapy Research, 35, 4, 2021. Crossref

  4. Saha Manas Ranjan, Dey Priyankar, Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota, Archives of Physiology and Biochemistry, 2021. Crossref

  5. Zhang Kun, Chen Xue-Lin, Zhao Xia, Ni Ji-Yan, Wang Han-Lei, Han Mei, Zhang Yu-Mei, Antidiabetic potential of Catechu via assays for α-glucosidase, α-amylase, and glucose uptake in adipocytes, Journal of Ethnopharmacology, 291, 2022. Crossref

  6. Islam Johirul, Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer, in Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 2022. Crossref

  7. Islam Johirul, Shree Alpa, Vafa Abul, Afzal Shekh M., Sultana Sarwat, Taxifolin ameliorates Benzo[a]pyrene-induced lung injury possibly via stimulating the Nrf2 signalling pathway, International Immunopharmacology, 96, 2021. Crossref

  8. Shree Alpa, Islam Johirul, Yadav Vikas, Sultana Sarwat, Khan Haider Ali, Hesperetin alleviates DMH induced toxicity via suppressing oxidative stress and inflammation in the colon of Wistar rats , Environmental Toxicology, 37, 9, 2022. Crossref

  9. Islam Johirul, Shree Alpa, Khan Haider Ali, Sultana Sarwat, Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice, Journal of Biochemical and Molecular Toxicology, 2022. Crossref

  10. Islam Johirul, Protective Effect of Quercetin, Luteolin, and Fisetin via Stimulating the p53-Mediated Signaling in Cancer, in Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 2022. Crossref

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