图书馆订阅: Guest
环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Hesperidin Protects Renal and Hepatic Tissues Against Free Radical-Mediated Oxidative Stress During DMBA-Induced Experimental Breast Cancer

卷 30, 册 4, 2011, pp. 283-300
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i4.20
Get accessGet access

摘要

Hesperidin has been reported to have an excellent and wide variety of biological activities. This property has brought the compound to a new stage in the treatment of various oxidative stress-mediated diseases. The present investigation was aimed to evaluate the therapeutic potential of hesperidin by assaying the activities of antioxidant enzymes, lipid peroxidation, membrane bound marker enzymes, adenosine triphosphates, and TCA cycle enzymes, especially in kidney tissues during 7,12-dimethybenz(a)anthracene-induced breast cancer. Daily oral administration of hesperidin (30 mg/kg body wt) to breast cancer-bearing rats for 45 days demonstrated a significant (P < .05) decline in renal lipid peroxidation and membrane bound marker enzymes, as well as a remarkable increase in adenosine triphosphatases, mitochondrial functional enzymes, and renal antioxidants. Furthermore, histological studies of liver and kidney provided evidence of biochemical alterations. Thus, the protective effects of hesperidin on attenuating the peroxidation reaction and membrane bound marker enzyme activities as well as upregulation of adenosine triphosphatases, TCA cycle enzymes, and antioxidants suggest promising uses of flavonoglycoside hesperidin in the future treatment of oxidative stress-mediated diseases.

对本文的引用
  1. Rengarajan Thamaraiselvan, Rajendran Peramaiyan, Nandakumar Natarajan, Balasubramanian Maruthaiveeran Periyasamy, Nishigaki Ikuo, Free radical scavenging and antioxidant activity of D-pinitol against 7, 12 dimethylbenz (a) anthracene induced breast cancer in sprague dawley rats, Asian Pacific Journal of Tropical Disease, 4, 5, 2014. Crossref

  2. Rajakumar Thangarasu, Pugalendhi Pachaiappan, Thilagavathi Subbaiyan, Dose response chemopreventive potential of allyl isothiocyanate against 7,12-dimethylbenz(a)anthracene induced mammary carcinogenesis in female Sprague-Dawley rats, Chemico-Biological Interactions, 231, 2015. Crossref

  3. Li Chaoyun, Schluesener Hermann, Health-promoting effects of the citrus flavanone hesperidin, Critical Reviews in Food Science and Nutrition, 57, 3, 2017. Crossref

  4. Cirmi Santa, Ferlazzo Nadia, Lombardo Giovanni, Maugeri Alessandro, Calapai Gioacchino, Gangemi Sebastiano, Navarra Michele, Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?, Nutrients, 8, 11, 2016. Crossref

  5. Vanitha Manickam Kalappan, Baskaran Kuppusamy, Periyasamy Kuppusamy, Selvaraj Sundaramoorthy, Ilakkia Aruldoss, Saravanan Dhiravidamani, Venkateswari Ramachandran, Revathi Mani Balasundaram, Anandakumar Pandi, Sakthisekaran Dhanapal, Modulatory Effect of Taurine on 7,12-Dimethylbenz(a)Anthracene-Induced Alterations in Detoxification Enzyme System, Membrane Bound Enzymes, Glycoprotein Profile and Proliferative Cell Nuclear Antigen in Rat Breast Tissue, Journal of Biochemical and Molecular Toxicology, 30, 8, 2016. Crossref

  6. Yi Lunzhao, Ma Shasha, Ren Dabing, Phytochemistry and bioactivity of Citrus flavonoids: a focus on antioxidant, anti-inflammatory, anticancer and cardiovascular protection activities, Phytochemistry Reviews, 16, 3, 2017. Crossref

  7. Khedr Naglaa Fathi, Protective effect of mirtazapine and hesperidin on cyclophosphamide-induced oxidative damage and infertility in rat ovaries, Experimental Biology and Medicine, 240, 12, 2015. Crossref

  8. Stanisic Danijela, Costa Amanda F., Cruz Guilherme, Durán Nelson, Tasic Ljubica, , 58, 2018. Crossref

  9. Yang Zhen, Yang Hongwei, Dong Xinhua, Pu Minglong, Ji Feihong, Hesperidin loaded Zn2+@ SA/PCT nanocomposites inhibit the proliferation and induces the apoptosis in colon cancer cells (HCT116) through the enhancement of pro-apoptotic protein expressions, Journal of Photochemistry and Photobiology B: Biology, 204, 2020. Crossref

  10. Hajialyani Marziyeh, Hosein Farzaei Mohammad, Echeverría Javier, Nabavi Seyed, Uriarte Eugenio, Sobarzo-Sánchez Eduardo, Hesperidin as a Neuroprotective Agent: A Review of Animal and Clinical Evidence, Molecules, 24, 3, 2019. Crossref

  11. Tundis Rosa, Acquaviva Rosaria, Bonesi Marco, Malfa Giuseppe Antonio, Tomasello Barbara, Loizzo Monica R., Citrus Flavanones, in Handbook of Dietary Phytochemicals, 2020. Crossref

  12. Akhouri Vivek, Kumar Arun, Kumari Manorma, Antitumour Property ofPterocarpus santalinusSeeds Against DMBA-Induced Breast Cancer in Rats, Breast Cancer: Basic and Clinical Research, 14, 2020. Crossref

  13. Akhouri Vivek, Kumari Manorma, Kumar Arun, Therapeutic effect of Aegle marmelos fruit extract against DMBA induced breast cancer in rats, Scientific Reports, 10, 1, 2020. Crossref

  14. Patel Pankti, Shah Jigna, Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats, Life Sciences, 285, 2021. Crossref

  15. Badawy Abdelnaser A., Othman Rashad Qasem Ali, El-Magd Mohammed A., Effect of combined therapy with camel milk-derived exosomes, tamoxifen, and hesperidin on breast cancer, Molecular & Cellular Toxicology, 2021. Crossref

  16. Tundis Rosa, Acquaviva Rosaria, Bonesi Marco, Malfa Giuseppe Antonio, Tomasello Barbara, Loizzo Monica R., Citrus Flavanones, in Handbook of Dietary Phytochemicals, 2021. Crossref

1076 文章浏览量 26 文章下载 统计数据
1076 文章浏览量 26 下载次数 16 Crossref 引用次数 Google
Scholar
引用次数

相似内容的文章:

Nephroprotective Effect of Jaggery against Acute and Subchronic Toxicity of Acetaminophen in Wistar Rats Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 3
Vinay Sharma, Dr. Chandra Kant Sharma
Naringenin Ameliorates Doxorubicin Toxicity and Hypoxic Condition in Dalton's Lymphoma Ascites Tumor Mouse Model: Evidence from Electron Paramagnetic Resonance Imaging Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 3
Kumaresan Ganesan, Venkatesan Kathiresan, Murugesan Ramachandran, Swathika Subburaman, Mathivanan Natarajan, Arun Venkatesh Krishna, Gandhidasan Rathinasamy
Toxic Effects of Lead Exposure in Rats: Involvement of Oxidative Stress, Genotoxic Effect, and the Beneficial Role of N-Acetylcysteine Supplemented with Selenium Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Samta Sharma, Bhanu Pratap Singh Raghuvanshi, Sangeeta Shukla
Diosgenin, a Steroidal Saponin, Exhibits Anticancer Activity by Attenuating Lipid Peroxidation Via Enhancing Antioxidant Defense System During NMU-Induced Breast Carcinoma Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 2
Jayaraman Jagadeesan, Thamaraiselvan Rengarajan, Maruthaiveeran Periyasamy Balasubramanian, Natarajan Nandakumar
Antioxidant and Hepatoprotective Effects of Crataegus songarica Methanol Extract Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 2
Akbar Masood, Ovais Zargar, Mohammad Afzal Zargar, Showkat Ahmad Ganie, Shajrul Amin, Parvaiz Ahmad Dar, Shayaq Ul Abeer, Rabia Hamid, Tanveer Ali Dar, Bilal Zargar
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain