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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.519 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.v25.i1-2.260
pages 411-424

Photodynamic Therapy of Nodular Basal Cell Carcinoma with Multifiber Contact Light Delivery

Marcelo Soto Thompson
Lund University Medical Laser Centre; Department of Physics, Lund Institute of Technology, SE-221 00 Lund, Sweden
Stefan Andersson-Engels
Lund University Medical Laser Centre; Department of Physics, Lund Institute of Technology, SE-221 00 Lund, Sweden
Sune Svanberg
Lund University Medical Laser Centre; Department of Physics, Lund Institute of Technology, SE-221 00 Lund, Sweden
T. Johansson
SpectraCure AB, Lund, Sweden
Sara Palsson
Lund University Medical Laser Centre; Department of Physics, Lund Institute of Technology, SE-221 00 Lund, Sweden; Science and Technology International, Honolulu, HI, 96813
Niels Bendsoe
Department of Dermatology, Lund University Hospital, Lund University Medical Laser Centre, SE-221 00 Lund, Sweden; Department of Dermatology, Lund University Hospital, SE-221 85 Lund, Sweden
A. Derjabo
Latvian Oncology Centre, Riga, Latvia
J. Kapostins
Latvian Oncology Centre, Riga, Latvia
Unne Stenram
Lund University Medical Laser Centre; Department of Pathology, Lund University Hospital, SE-221 85 Lund, Sweden
J. Spigulis
Institute of Atomic Physics and Spectroscopy, University of Latvia, Riga, Latvia
Katarina Svanberg
Lund University Medical Laser Centre; Department of Oncology, Lund University Hospital, SE-221 85 Lund, Sweden

ABSTRACT

To overcome the limited treatment depth of superficial photodynamic therapy we investigate interstitial light delivery. In the present work the treatment light was delivered using a system in which three or six clear-cut fibers were placed in direct contact with the tumor area. This placement was thought to represent a step toward general purpose interstitial PDT. Twelve nodular basal cell carcinomas were treated employing δ-aminolevulinic acid and 635 nm laser irradiation. Fluorescence measurements were performed monitoring the buildup and subsequent bleaching of the produced sensitizer protoporphyrin IX. The treatment efficacy, judged at a 28-month follow-up, showed a 100% complete response. Two punch excisions at 7 months converted two partial responses to complete responses. One patient failed to appear at all follow-up sessions. The outcome of the treatments was comparable to superficial photodynamic therapy in terms of histological, clinical, and cosmetic results.


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