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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2015012673
pages 237-248

Development of an Anti-Atherosclerotic Polyherbal Formulation: GSTC3

Jeksy J. Manalil
Amala Cancer Research Centre (Recognized by University of Calicut, Kerala), Amala Nagar, Kerala, India
Merin Baby
Amala Cancer Research Centre (Recognized by University of Calicut, Kerala), Amala Nagar, Kerala, India
Smitha K. Ramavarma
Amala Cancer Research Centre (Recognized by University of Calicut, Kerala), Amala Nagar, Kerala, India
Indu M. Suseela
Amala Cancer Research Centre (Recognized by University of Calicut, Kerala), Amala Nagar, Kerala, India
Jose Padikkala
Department of Biochemistry, Amala Cancer Research Centre, Thrissur
Achuthan C. Raghavamenon
Department of Biochemistry, Amala Cancer Research Centre, Thrissur

ABSTRACT

A polyherbal formulation consisting of different proportions of Commiphora mukul (Hook ex Stocks) Eng., Salacia reticulata Wight, Terminalia arjuna (Roxb.) Wight & Arn, and Curcuma longa Linn extracts was tested for free-radical scavenging and anti-lipid peroxidative effects on serum and platelets in vitro. The most active formulation (GSTC3) was evaluated for its hypolipidemic potential on a high-fat, high-cholesterol diet (HFD) fed to male Wistar rats for a period of 45 days. At a dose of 100 mg/kg body weight, GSTC3 decreased serum total cholesterol, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), triglycerides, and phospholipids similar to standard atorvastatin while maintaining high-density lipoprotein (HDL) at normal levels. Significantly lower levels of thiobarbituric acid−reactive substances (TBARS) were observed in both the liver and sera of rats treated with GSTC3. Although the phospholipid levels in liver remained unchanged, lower values of LDL, VLDL, and atherogenic index of plasma as well as higher HMG-CoA/ mevalonate ratios suggested a significant hypolipidemic effect for GSTC3, possibly by partial inhibition of HMG-CoA reductase activity. The histopathological analysis of liver tissue did not reveal lipid accumulation or indicate tissue damage. Overall, the results of this study suggest the hypolipidemic and anti-atherogenic efficacy of a nontoxic herbal formulation.


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