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环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Relevance of Radioprotectors in Radiotherapy: Studies with Tocopherol Monoglucoside

卷 23, 册 2, 2004, 8 pages
DOI: 10.1615/JEnvPathToxOncol.v23.i2.80
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摘要

Radioprotective compounds are of importance in clinical radiation therapy, because normal tissues should be protected against radiation injury while using higher doses of radiation to obtain better cancer control. We investigated the radioprotection of cellular DNA in cancer and in various cells and tissues, in a murine system following exposure to γ-radiation and tocopherol monoglucoside (TMG) administration. We used single-cell gel electrophoresis (comet assay) and studied the progression of murine fibrosarcoma following radiation exposure and administration of TMG. The administration of TMG to tumor-bearing mice protected the cellular DNA against radiation-induced strand breaks as shown by the decrease in comet tail length, tail moment, and percentage of DNA in the tails of the cells of normal tissues. The same parameters were not altered in the cells of fibrosarcoma. Our results showed that the administration of TMG immediately after exposure to γ-radiation can protect normal tissues against radiation damages in tumor-bearing mice. Local γ-radiation exposure (5 Gy) of the tumor retarded the tumor growth. Administration of TMG did not protect cancer cells from radiation damage because the growth curves of cancer cells treated with radiation alone and those treated with TMG after irradiation were not significantly different.

对本文的引用
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  2. Nair Cherupally Krishnan Krishnan, Salvi Veena Prakash, Protection of DNA from gamma-radiation induced strand breaks by Epicatechin, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 650, 1, 2008. Crossref

  3. Singh Vijay K., Brown Darren S., Kao Tzu-Cheg, Tocopherol succinate: A promising radiation countermeasure, International Immunopharmacology, 9, 12, 2009. Crossref

  4. Nair Gopakumar Gopinathan, Nair Cherupally Krishnan Krishnan, Protection of Cellular DNA and Membrane from γ-Radiation–Induced Damages and Enhancement in DNA Repair by Sesamol, Cancer Biotherapy and Radiopharmaceuticals, 25, 6, 2010. Crossref

  5. Sandeep Divyasree, Nair Cherupally Krishnan Krishnan, Protection from lethal and sub-lethal whole body exposures of mice to γ-radiation by Acorus calamus L.: Studies on tissue antioxidant status and cellular DNA damage, Experimental and Toxicologic Pathology, 64, 1-2, 2012. Crossref

  6. Maurya Dharmendra Kumar, Devasagayam Thomas Paul Asir, Ferulic Acid Inhibits Gamma Radiation-Induced DNA Strand Breaks and Enhances the Survival of Mice, Cancer Biotherapy and Radiopharmaceuticals, 28, 1, 2013. Crossref

  7. Singh Pankaj K., Krishnan Sunil, Vitamin E Analogs as Radiation Response Modifiers, Evidence-Based Complementary and Alternative Medicine, 2015, 2015. Crossref

  8. ANZAI Kazunori, IKOTA Nobuo, UENO Megumi, NYUI Minako, KAGIYA Tsutomu V., Heat-Treated Mineral-Yeast as a Potent Post-irradiation Radioprotector, Journal of Radiation Research, 49, 4, 2008. Crossref

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