图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvPathToxOncol.v23.i1.50
8 pages

Expression of NF-κB and ERK Following Heavy Ion Irradiation

Anirban Kumar Mitra
Radiation Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
Asiti Sarma
Nuclear Science Centre, New Delhi, India
Malini Krishna
Radioprotection and Decontamination Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai-400085, India
Naresh C. Verma
Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai, Pin. (400 085), India

ABSTRACT

Heavy ion irradiation of cells is known to increase cytotoxic, mutagenic, and carcinogenic effects. The increased biological effectiveness of these ions is as yet unexplained, except for the fact that, unlike γ-radiation, they result in clustered damage. It is likely that the increased biological effectiveness is a consequence of altered signaling pattern, which in turn may be due to the difference in the nature of damage produced. Gamma irradiation has been known to activate both pro- and anti-apoptotic signaling pathways. Nuclear factor-κB (NF-κB) and extracellular signal regulated kinase (ERK) contribute to the survival of the irradiated cell. Moreover, NF-κB acts as a redox sensor. In the present study, we examined NF-κB and ERK as antiapoptotic factors that could lead to the inhibition of apoptosis and, consequently, to increased mutagenicity. Both these signaling factors show a fluctuation in their levels with time.


Articles with similar content:

Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 2
T. P. Hamsa, Girija Kuttan
Effects of Nickel-Smelting Fumes on the Regulation of NIH/3T3 Cell Viability, Necrosis, and Expression of hMLH1 and RASSF1A
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 1
Xue-Ying Hu, Yong-Hui Wu, Cui-Ping Yu, Jun Wang
Siva-1 Promotes K-48 Polyubiquitination of TRAF2 and Inhibits TCR-Mediated Activation of NF-kappaB
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Prasad Kanteti, John Barkinge, Radhika Gudi, Sarah Hawkins, Bellur Prabhakar
Neutrophil Apoptosis and Hypoxia
International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 4
Andrey Polyakov, Larissa Dyugovskaya
Oncogene-lnitiated Aberrant Signaling Engenders the Metastatic Phenotype: Synergistic Transcription Factor Interactions are Targets for Cancer Therapy
Critical Reviews™ in Oncogenesis, Vol.7, 1996, issue 3-4
David T. Denhardt