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环境病理学,毒理学和肿瘤学期刊
影响因子: 1.241 5年影响因子: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.v20.iSuppl.1.10
14 pages

Time Course of Pulmonary Response of Rats to Inhalation of Crystalline Silica: Histological Results and Biochemical Indices of Damage, Lipidosis, and Fibrosis

Dale W. Porter
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Dawn Ramsey
National Institute for Occupational Safety and Health: Division of Applied Research and Technology, Cincinnati, OH
Ann F. Hubbs
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Lori Battelli
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Jane Ma
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Mark Barger
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Douglas Landsittel
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Victor A. Robinson
National Institute for Occupational Safety and Health: Health Effects Laboratory Division, Morgantown,WV
Je. McLaurin
National Institute for Occupational Safety and Health: Division of Applied Research and Technology, Cincinnati, OH
Amir Khan
National Institute for Occupational Safety and Health: Division of Applied Research and Technology, Cincinnati, OH
William Jones
National Institute for Occupational Safety and Health: Division of Respiratory Disease Studies, Morgantown, WV
Alexander Teass
National Institute for Occupational Safety and Health: Division of Applied Research and Technology, Cincinnati, OH
Vincent Castranova
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505

ABSTRACT

Previous studies have determined that a-quartz (crystalline silica) can cause pulmonary inflammation, damage, and fibrosis. However, the temporal relationship between silica inhalation and pulmonary inflammation, damage, and fibrosis has not been fully examined. To address this gap in our knowledge of silica-induced pulmonary fibrosis, a chronic inhalation study using rats was designed. Specifically, rats were exposed to a silica aerosol (15 mg/m3 silica, 6 h/d, 5d/wk, 116 d), and measurements of pulmonary inflammation, damage, and fibrosis were monitored throughout the study. We report (1) data demonstrating that the silica aerosol generation and exposure system produced a consistent silica aerosol of respirable size particles; (2) the time course of silica deposition in the lung; (3) calculations that demonstrate that the rats were not in pulmonary overload; (4) histopathological data demonstrating time-dependent enhancement of silica-induced alveolitis, epithelial hypertrophy and hyperplasia, alveolar lipoproteinosis, and pulmonary fibrosis in the absence of overload; and (5) biochemical data documenting the development of lipidosis, lung damage, and fibrosis.


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