每年出版 4 期
ISSN 打印: 0731-8898
ISSN 在线: 2162-6537
Indexed in
Cellular and Molecular Mechanisms Regulating Silica-Induced Adhesion Molecule Expression in Mice
摘要
Exposure of mice to silica particles generates an intense inflammatory response characterized by the influx of neutrophils and monocytes into the alveoli with resulting cell activation. These cell trafficking and effector functions are, in part, mediated by different families of adhesion molecules. One such adhesion protein, intercellular adhesion molecule-1 (ICAM-1), is expressed on a variety of cells including vascular endothelial cells, fibroblasts, types I and II alveolar epithelial cells, some lymphocytes, and monocytes/macrophages. Over the last several years, our laboratory has focused on silica-induced ICAM-1 expression in exposed mice (in vivo) and cells (in vitro) by examining the role and regulation of this adhesion protein on pulmonary cells.We have determined that intratracheal exposure of mice to silica (2 mg per mouse) elicits increased expression of ICAM-1 on pulmonary macrophages and type II epithelial cells within the lung parenchyma, on bronchoalveolar lavage macrophages, and as a soluble protein in lavage fluid.We hypothesize that increased ICAM-1 expression may participate in silica-induced neutrophil influx into the alveoli, as well as in macrophage-derived phlogistic signals responsible for migration of neutrophils. ICAM-1 expression on silica-exposed mouse macrophages is enhanced by reactive oxygen species (ROS) and tumor necrosis factor-a (TNF-a) and appears to be regulated through specific sequence elements within the ICAM-1 promoter.
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Fujii Takeshi, Hogg James C., Keicho Naoto, Vincent Renaud, Van Eeden Stephan F., Hayashi Shizu, Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10, American Journal of Physiology-Lung Cellular and Molecular Physiology, 284, 2, 2003. Crossref
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Zhang Shu-kun, Zhuo Yu-zhen, Li Cai-xia, Yang Lei, Gao Hong-wei, Wang Xi-mo, Xuebijing Injection (血必净注射液) and Resolvin D1 Synergize Regulate Leukocyte Adhesion and Improve Survival Rate in Mice with Sepsis-Induced Lung Injury, Chinese Journal of Integrative Medicine, 24, 4, 2018. Crossref
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Ishii Hiroshi, Fujii Takeshi, Hogg James C., Hayashi Shizu, Mukae Hiroshi, Vincent Renaud, van Eeden Stephan F., Contribution of IL-1β and TNF-α to the initiation of the peripheral lung response to atmospheric particulates (PM10), American Journal of Physiology-Lung Cellular and Molecular Physiology, 287, 1, 2004. Crossref