图书馆订阅: Guest
环境病理学,毒理学和肿瘤学期刊

每年出版 4 

ISSN 打印: 0731-8898

ISSN 在线: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Cellular and Molecular Mechanisms Regulating Silica-Induced Adhesion Molecule Expression in Mice

卷 20, 册 Suppl.1, 2001, 8 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v20.iSuppl.1.40
Get accessGet access

摘要

Exposure of mice to silica particles generates an intense inflammatory response characterized by the influx of neutrophils and monocytes into the alveoli with resulting cell activation. These cell trafficking and effector functions are, in part, mediated by different families of adhesion molecules. One such adhesion protein, intercellular adhesion molecule-1 (ICAM-1), is expressed on a variety of cells including vascular endothelial cells, fibroblasts, types I and II alveolar epithelial cells, some lymphocytes, and monocytes/macrophages. Over the last several years, our laboratory has focused on silica-induced ICAM-1 expression in exposed mice (in vivo) and cells (in vitro) by examining the role and regulation of this adhesion protein on pulmonary cells.We have determined that intratracheal exposure of mice to silica (2 mg per mouse) elicits increased expression of ICAM-1 on pulmonary macrophages and type II epithelial cells within the lung parenchyma, on bronchoalveolar lavage macrophages, and as a soluble protein in lavage fluid.We hypothesize that increased ICAM-1 expression may participate in silica-induced neutrophil influx into the alveoli, as well as in macrophage-derived phlogistic signals responsible for migration of neutrophils. ICAM-1 expression on silica-exposed mouse macrophages is enhanced by reactive oxygen species (ROS) and tumor necrosis factor-a (TNF-a) and appears to be regulated through specific sequence elements within the ICAM-1 promoter.

对本文的引用
  1. Fujii Takeshi, Hogg James C., Keicho Naoto, Vincent Renaud, Van Eeden Stephan F., Hayashi Shizu, Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10, American Journal of Physiology-Lung Cellular and Molecular Physiology, 284, 2, 2003. Crossref

  2. Zhang Shu-kun, Zhuo Yu-zhen, Li Cai-xia, Yang Lei, Gao Hong-wei, Wang Xi-mo, Xuebijing Injection (血必净注射液) and Resolvin D1 Synergize Regulate Leukocyte Adhesion and Improve Survival Rate in Mice with Sepsis-Induced Lung Injury, Chinese Journal of Integrative Medicine, 24, 4, 2018. Crossref

  3. Ishii Hiroshi, Fujii Takeshi, Hogg James C., Hayashi Shizu, Mukae Hiroshi, Vincent Renaud, van Eeden Stephan F., Contribution of IL-1β and TNF-α to the initiation of the peripheral lung response to atmospheric particulates (PM10), American Journal of Physiology-Lung Cellular and Molecular Physiology, 287, 1, 2004. Crossref

Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain