图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
环境病理学,毒理学和肿瘤学期刊
影响因子: 1.625 5年影响因子: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN 打印: 0731-8898
ISSN 在线: 2162-6537

环境病理学,毒理学和肿瘤学期刊

DOI: 10.1615/JEnvironPatholToxicolOncol.2013006505
pages 73-90

Pre- and Postnatal Toxicity of Diazinon Induces Disruption of Spermatogenetic Cell Line Evidenced by Increased Testicular Marker Enzymes Activities in Rat Offspring

Srinivasa Jayachandra
School of Medicine, Universiti Malaysia Sabah, 88400 Kota Kinabalu Sabah, Malaysia
Urban JA D'Souza
School of Medicine, Universiti Malaysia Sabah, 88400 Kota Kinabalu Sabah, Malaysia

ABSTRACT

The objective of this study was to study the possible reproductive adverse effects of the diazinon on rat offspring exposed in utero and during lactation. Dams were gavaged daily (10, 15, and 30 mg/kg) before mating, during mating, and during pregnancy and lactation in separate groups. Reproductive outcome data of dams were examined. Body weight, testis weight, testicular marker enzyme activities (alkaline phosphatase, acid phosphatase, lactate dehydrogenase, and glucose-6-phosphate dehydrogenase), qualitative and quantitative testicular and epididymal histology, and immunohistochemisty for 3-β-hydroxysteroid dehydrogenase (HSD) were examined in male offspring at puberty and adulthood. The 30-mg/kg dose induced significant adverse effects at both puberty and adulthood in offspring. At puberty the male offspring showed a decrease in testicular weight, degenerative changes, and 3-β-HSD. Moreover, an increase in activity of alkaline and acid phosphatase also was observed. At adulthood, there was a decrease in testicular weight and 3-β-HSD with an increase in the levels of testicular marker enzyme. There was evidence of some adverse reproductive effects in male offspring at the 15-mg/kg dose. Most of the adverse effects were irreversible and were evident at both puberty and adulthood in offspring, although a few parameters reverted back to the normal growth pattern. Hence, diazinon is a reproductive toxicant in male offspring, which caused significant damage to the testes when exposed during prenatal and postnatal life.


Articles with similar content:

Protective Effects of Extract from Sclerotium of the King Tuber Medicinal Mushroom, Pleurotus tuberregium (Higher Basidiomycetes) on Carbon Tetrachloride-Induced Hepatotoxicity in Wistar Albino Rats
International Journal of Medicinal Mushrooms, Vol.17, 2015, issue 12
Christopher C. Osubor, Chidube A. Alagbaoso, Omoanghe S. Isikhuemhen
Antitumor Initiating Potential of Rosmarinic Acid in 7,12-Dimethylbenz(a)anthracene-Induced Hamster Buccal Pouch Carcinogenesis
Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 3
Shanmugam Manoharan, Chezhiyan Anusuya
Effects of Concurrently Administered Aqueous Extract of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Lead Acetate in Rats
International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 2
Michael T. Sobowale, Raymond I. Ozolua, Buniyamin A. Ayinde, Dickson O. Uwaya
Dose-Dependent Effects of Ethanol on Lead-Induced Oxidative Stress in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Swaran Flora, Pratibha Gautam, Nidhi Dwivedi
Alterations in Bronchoalveolar Lavage Constituents, Oxidant/Antioxidant Status, and Lung Histology Following Intratracheal Instillation of Respirable Suspended Particulate Matter
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 1
Jawahir Lal Kaw, Ashok Kumar Khanna, Anupam Pradhan, Shashi Dogra, Mohd Waseem