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免疫病理疾病及治疗学论文学
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN 打印: 2151-8017
ISSN 在线: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

免疫病理疾病及治疗学论文学

DOI: 10.1615/ForumImmunDisTher.2012004386
pages 281-301

Natural Products as Inhibitors of Epidermal Growth Factor Receptor

Thomas Efferth
Department of Pharmaceutical Biology Institute of Pharmacy and Biochemistry Johannes Gutenberg University, Mainz, Germany

ABSTRACT

The epidermal growth factor receptor (EGFR) and its ligand are signaling molecules involved in several crucial functions in cancer biology, including cell proliferation, differentiation, invasion and metastasis, and suppression of apoptosis. Overexpression and activation of EFGR in tumors is associated with poor prognosis of patients. Therefore, EGFR represents an important molecular target for treatment in clinical oncology. Several EGFR inhibitors have been developed and clinically approved during recent years. Unfortunately, tumors develop resistance against EGFR small-molecule inhibitors due to point mutations in the tyrosine kinase domain of the receptor. Therefore, the development of novel EGFR tyrosine kinase inhibitors with activity to otherwise resistant EGFR mutated tumors is urgently required. As the majority of anticancer drugs are of natural origin, natural products are a valuable source for the identification and development of novel treatment options for cancer. Here, we give an overview on natural products derived from medicinal herbs, food sources, marine organisms, or microorganisms that are able to inhibit EGFR signaling. Molecular modes of action in cell lines, tumor activities in animal experiments, as well as derivatives of EGFR-inhibiting natural products are discussed.


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