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免疫病理疾病及治疗学论文学
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN 打印: 2151-8017
ISSN 在线: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

免疫病理疾病及治疗学论文学

DOI: 10.1615/ForumImmunDisTher.2013008382
pages 181-196

Role of NF-κB in Tumorigenesis

Muthu K. Shanmugam
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
Alan P. Kumar
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599
Benny K. H. Tan
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
Gautam Sethi
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597; Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, Singapore 117599

ABSTRACT

Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer.


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