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器官移植长期效应期刊
SJR: 0.145 SNIP: 0.491 CiteScore™: 0.89

ISSN 打印: 1050-6934
ISSN 在线: 1940-4379

器官移植长期效应期刊

DOI: 10.1615/JLongTermEffMedImplants.v12.i4.60
9 pages

Incidence of Breast and Other Cancers Among Finnish Women with Cosmetic Breast Implants, 1970–1999

Eero Pukkala
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki
John D. Boice
International Epidemiology Institute, Rockville, Maryland; and Department of Medicine and Vanderbilt—Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Sirpa-Liisa Hovi
National Research and Development Centre for Welfare and Health (STAKES), Helsinki
Elina Hemminki
National Research and Development Centre for Welfare and Health (STAKES), Helsinki
Sirpa Asko-Seljavaara
Helsinki University Central Hospital, Department of Plastic Surgery
Ilmo Keskimaki
National Research and Development Centre for Welfare and Health (STAKES), Helsinki
Joseph K. McLaughlin
Professor of Medicine, Vanderbilt Medical School, President, International Epidemiology Institute, 1455 Research Blvd., Suite 550, Rockville, Maryland, 20850-3127, USA
Matti Pakkanen
Hospital Siluetti, Suomen Kirurgipalvelu Oy; and Clinic of Plastic and Aesthetic Surgery, Helsinki, Finland
Lyly Teppo
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland

ABSTRACT

Epidemiologic evidence does not point to a carcinogenic effect of silicone implants on the breast, and evidence for or against a carcinogenic effect at sites other than the breast is limited. To examine subsequent cancer risk among women with cosmetic breast implants, we conducted a cohort study of 2171 women in Finland identified from operation diaries of major hospitals and private clinics, 1970–1999. B e nationwide population and health outcome registries in Finland were used to trace these women for cancer incidence through 1999. Standard statistical techniques were used to compute expected values based on general population rates. B e measure of risk was taken as the ratio of observed to expected cancers, that is, the standardized incidence ratio (SIR) and its 95% confidence interval (CI). Among the 2171 women with cosmetic breast implants, 30 developed cancer against 33.7 expected (SIR = 0.9, 95% CI = 0.6–1.3). There was no evidence for an increase in breast cancer risk (SIR 0.5, 95% CI, 0.2–1.0), even among those followed for more than 10 years (2 observed, 4.6 expected). Stage at breast cancer diagnosis did not differ from that expected nor did incidence of any other cancer. Although hindered by small numbers, the consistency of our results with those of other Nordic studies leads us to conclude that cosmetic breast implants are not a cause of cancer and that they do not appear to delay the detection of breast cancers.


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