每年出版 4 期
ISSN 打印: 1050-6934
ISSN 在线: 1940-4379
Indexed in
Viscosupplementation for Knee Osteoarthritis: Current Evidence and Recommendations
摘要
Osteoarthritis (OA) is the most common joint disorder worldwide and is a leading cause of pain and disability. Appropriate management of younger patients with milder disease remains a challenging area of intense research. Viscosupplementation attempts to restore the biomechanical and biochemical functions of normal synovial fluid hyaluronic acid. Several preparations with varying characteristics are currently available. The literature suggests a small benefit and relative safety, but several recent large meta-analyses have reported conflicting results. Major clinical guidelines provide inconclusive recommendations. Viscosupplementation may be a viable option in younger patients with milder OA where other non-operative modalities are also only modestly successful, but further investigation is clearly warranted. Limitations due to study heterogeneity, outcome reporting, and bias can each be addressed with improved research methodology.
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McElheny Kathryn, Toresdahl Brett, Ling Daphne, Mages Keith, Asif Irfan, Comparative Effectiveness of Alternative Dosing Regimens of Hyaluronic Acid Injections for Knee Osteoarthritis: A Systematic Review, Sports Health: A Multidisciplinary Approach, 11, 5, 2019. Crossref