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器官移植长期效应期刊
SJR: 0.133 SNIP: 0.491 CiteScore™: 0.89

ISSN 打印: 1050-6934
ISSN 在线: 1940-4379

器官移植长期效应期刊

DOI: 10.1615/JLongTermEffMedImplants.v13.i5.50
14 pages

Fibrin Sealant Reduces Perioperative Blood Loss in Total Hip Replacement

Gwo-Jaw Wang
Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA
Charles A. Goldthwaite, Jr.
Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA
Sandra G. Burks
Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA
Ross Crawford
Department of Biomedical Engineering, University of Technology, Queensland, Australia
William D. Spotnitz
Division of Thoracic and Cardiovascular Surgery, University of Florida; Surgical Therapeutic Advancement Center, University of Virginia, Charlottesville, Virginia, USA

ABSTRACT

Patients (n = 81) undergoing total hip replacement (THR) were randomized to receive either standard of care plus fibrin sealant (FS) (10 mL total) or standard of care alone to evaluate the efficacy of FS for reducing blood loss in THR. Considering the 81 intent-to-treat patients, adjusted perioperative blood loss was reduced significantly in the FS group, by 197 mL [95% CI: 45 mL, 319 mL] or 23.5% [95% CI: 5.4%, 38.1%] (p = 0.014). When protocol violators were eliminated, leaving 73 patients, the adjusted FS group perioperative bleeding was reduced by 221 mL [95% CI: 63 mL, 351 mL] or 27.1% [95% CI: 7.6%, 42.5%] (p = 0.0098).


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