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Role of NF-κB in Tumorigenesis

卷 4, 册 2, 2013, pp. 181-196
DOI: 10.1615/ForumImmunDisTher.2013008382
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摘要

Persistent activation of the pro-inflammatory transcription factor nuclear factor-κB (NF-κB) is frequently observed in several human malignancies and can drive the processes of tumor initiation, oncogenic transformation, and malignant progression. Once activated, this master transcription factor regulates the expression of numerous genes involved in proliferation, survival, metastasis, angiogenesis, chemoresistance, and radioresistance. Thus, novel pharmacological agents that can suppress constitutive and/or inducible NF-κB activation have the potential for cancer therapy. In this review, we describe in detail the pleiotropic molecular mechanisms of aberrant NF-κB activation and also discuss various therapeutic strategies employed to suppress deregulated activation of this important oncogenic transcription factor in cancer.

对本文的引用
  1. Shanmugam Muthu K., Ahn Kwang S., Lee Jong H., Kannaiyan Radhamani, Mustafa Nurulhuda, Manu Kanjoormana A., Siveen Kodappully S., Sethi Gautam, Chng Wee J., Kumar Alan P., Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma, Frontiers in Pharmacology, 9, 2018. Crossref

  2. Shanmugam Muthu K., Ahn Kwang Seok, Hsu Annie, Woo Chern Chiuh, Yuan Yi, Tan Kwong Huat Benny, Chinnathambi Arunachalam, Alahmadi Tahani Awad, Alharbi Sulaiman Ali, Koh Angele Pei Fern, Arfuso Frank, Huang Ruby Yun-Ju, Lim Lina H. K., Sethi Gautam, Kumar Alan Prem, Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis, Frontiers in Pharmacology, 9, 2018. Crossref

  3. Jung Young Yun, Shanmugam Muthu K., Chinnathambi Arunachalam, Alharbi Sulaiman Ali, Shair Omar H.M., Um Jae-Young, Sethi Gautam, Ahn Kwang Seok, Fangchinoline, a Bisbenzylisoquinoline Alkaloid can Modulate Cytokine-Impelled Apoptosis via the Dual Regulation of NF-κB and AP-1 Pathways, Molecules, 24, 17, 2019. Crossref

  4. Sethi Gautam, Shanmugam Muthu K., Arfuso Frank, Kumar Alan Prem, Role of RNF20 in cancer development and progression – a comprehensive review, Bioscience Reports, 38, 4, 2018. Crossref

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