图书馆订阅: Guest

Stable Water Clusters−Mediated Molecular Alterations in Human Melanoma Cell Lines

卷 3, 册 3-4, 2012, pp. 253-259
DOI: 10.1615/ForumImmunDisTher.2013007833
Get accessGet access

摘要

Several reports have shown that the formation of stable water clusters (SWC) of different sizes underlie their physical and chemical properties, such as temperature-related density and anomalous melting at high temperature. Among the SWCs, one produces a double helix (DH), a structure that has been studied in a variety of biological systems. The major objective of this preliminary study was to investigate the effects of SWCs on several phenotypic and molecular characteristics of human cancer cell lines. Our previous findings have demonstrated that very high dilutions of chemical/biological agents, while having no direct observed effects on human cellular systems, can nevertheless induce molecular and genetic changes that contribute to signaling by other stimuli. These findings suggested that cells can respond to relatively fewer molecules than physiological levels comprising of high number of molecules. Accordingly, we hypothesized that treatment of cells with a water preparation containing SWCs would induce molecular and genetic changes in human cellular systems. This hypothesis was tested using human melanoma cell lines as a model for an in vitro analysis. We examined the effect of SWCs on cell viability, proliferation, expression of immune death receptors and response to deathligand−induced apoptosis. In addition, we examined whether genetic changes might have also taken place. The preliminary findings demonstrate that treatment of melanoma cell lines with SWCs inhibits cell proliferation, upregulates the expression of death receptors, sensitizes the tumor cells to FasL-induced apoptosis, and selectively modifies gene products that regulate growth and the apoptotic pathways.

对本文的引用
  1. Lo Shui-Yin, Reply to the Comment by F. Kožíšek et al. on “Evidence for the existence of stable-water-clusters at room temperature and normal pressure” [Phys. Lett. A 373 (2009) 3872], Physics Letters A, 377, 39, 2013. Crossref

1302 文章浏览量 7 文章下载 统计数据
1302 文章浏览量 7 下载次数 1 Crossref 引用次数 Google
Scholar
引用次数

相似内容的文章:

Angiogenesis-Centered Molecular Cross-Talk in Amyotrophic Lateral Sclerosis Survival: Mechanistic Insights Critical Reviews™ in Eukaryotic Gene Expression, Vol.30, 2020, issue 2
Kaushal Sharma, Keshav Thakur, Abha Tiwari, Radhika Khosla, Akshay Anand, Shweta Modgil
Sinigrin Impedes the Breast Cancer Cell Growth through the Inhibition of PI3K/AKT/mTOR Phosphorylation-Mediated Cell Cycle Arrest Journal of Environmental Pathology, Toxicology and Oncology, Vol.41, 2022, issue 3
Jiawen Lin, Shuqin Li, Lingzhi Zhou, Peishun Wang, Shaohua Qu, Jiaofei Wei
In Vitro Cytotoxic Activity of an Aqueous Alkali Extract of the Tinder Conk Mushroom, Fomes fomentarius (Agaricomycetes), on Murine Fibroblasts, Human Colorectal Adenocarcinoma, and Cutaneous Melanoma Cells International Journal of Medicinal Mushrooms, Vol.24, 2022, issue 9
Liudmila Kalitukha, Anne Krüger-Genge, Joachim Storsberg
Plasma-Activated Medium Selectively Kills Glioblastoma Brain Tumor Cells by Down-Regulating a Survival Signaling Molecule, AKT Kinase Plasma Medicine, Vol.1, 2011, issue 3-4
Masaru Hori, Hiromasa Tanaka, Hiroaki Kajiyama, Kenji Ishikawa, Masaaki Mizuno, Hiroyuki Kano, Kae Nakamura, Fumitaka Kikkawa
Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway Journal of Environmental Pathology, Toxicology and Oncology, Vol.39, 2020, issue 2
Ruike Wang, Jiping Yang, Zhenzhen Liu, Ying Shao, Lisah Chew, Xiaomei Shao
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain