图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.v29.i4.10
pages 275-305

Chlamydial Infection of Immune Cells: Altered Function and Implications for Disease

Kenneth Beagley
Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
Wilhelmina M. Huston
Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia
Philip M. Hansbro
Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, Newcastle, NSW 2305, Australia; School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, NSW 2308, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo NSW, Australia
Peter Timms
Institute of Health and Biomedical Innovation, Queensland University of Technology, Australia

ABSTRACT

Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects the genital and ocular mucosa of humans, causing infections that can lead to pelvic inflammatory disease, infertility, and blinding trachoma. C. pneumoniae is a respiratory pathogen that is the cause of 12−15% of community-acquired pneumonia. Both chlamydial species were believed to be restricted to the epithelia of the genital, ocular, and respiratory mucosa; however, increasing evidence suggests that both these pathogens can be isolated from peripheral blood of both healthy individuals and patients with inflammatory conditions such as coronary artery disease and asthma. Chlamydia can also be isolated from brain tissues of patients with degenerative neurological disorders such as Alzheimer's disease and multiple sclerosis, and also from certain lymphomas. An increasing number of in vitro studies suggest that some chlamydial species can infect immune cells, at least at low levels. These infections may alter immune cell function in a way that promotes chlamydial persistence in the host and contributes to the progression of several chronic inflammatory diseases. In this paper, we review the evidence for the growth of Chlamydia in immune cells, particularly monocytes/macrophages and dendritic cells, and describe how infection may affect the function of these cells.


Articles with similar content:

IL-7 and IL-15: Biology and Roles in T-Cell Immunity in Health and Disease
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Kyung-A Hwang, Insoo Kang, Sung-Hwan Park, Hang-Rae Kim
Autoimmune Hepatitis: Factors Involved in Initiation and Methods of Diagnosis and Treatment
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Marilina Tampoia, Franco Dammacco, Gianfranco Lauletta, Fabio Pavone, Sabino Russi, Andrea Marzullo, Domenico Sansonno
Effects of Ultraviolet Exposure on the Immune System
Critical Reviews™ in Immunology, Vol.21, 2001, issue 4
Johan Garssen, Henk van Loveren
Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design
Critical Reviews™ in Immunology, Vol.35, 2015, issue 3
Claudia A. Riedel, Christian E. Palavecino, Alexis M. Kalergis, Susan M. Bueno, Pablo F. Cespedes, Margarita K. Lay
Expression and Function of Recombination Activating Genes in Mature В Cells
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
Masaki Hikida, Hitoshi Ohmori