图书馆订阅: Guest
免疫学评论综述™

每年出版 6 

ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Host Immune Responses to the Intracellular Bacteria Brucella: Does the Bacteria Instruct the Host to Facilitate Chronic Infection?

卷 26, 册 5, 2006, pp. 407-442
DOI: 10.1615/CritRevImmunol.v26.i5.30
Get accessGet access

摘要

Brucella spp. are intracellular gram-negative bacteria that include a number of virulent species that cause chronic infections in a variety of mammalian hosts. Human infections are proportional to the level of disease in domestic animals because humans are infected zoonotically after contact with infected animals or their products. The chronicity of infection results from the ability of some brucellae to survive reactive oxygen intermediate and nitric oxide killing in host phagocytes, following which they activate bacterial genes in response to the acidic phagosome environment, prevent phagolysosomal fusion by remodeling the intracellular compartment, and subsequently replicate intracellularly. The crucial component of immunity that results in survival of the host and thus maintenance of this chronic infective state is interferon-γ (IFN-γ). Production of IFN-γ results from the ability of brucella components, including lipid A, to interact with Toll-like receptors for the production of IL-12 and TNF-α, although the regulatory cytokine IL-10 is also produced and decreases control of the infection. Although CD4 and CD8 T cells are clearly involved in the production of IFN-γ, and CD8 T cells may be cytotoxic, a role for NK cells and cytotoxicity in protective immunity to brucellosis has not been substantiated experimentally. Moreover, antibodies have been shown to have a limited role in passive transfer studies.

对本文的引用
  1. Goel Divya, Rajendran Vinoth, Ghosh Prahlad C., Bhatnagar Rakesh, Cell mediated immune response after challenge in Omp25 liposome immunized mice contributes to protection against virulent Brucella abortus 544, Vaccine, 31, 8, 2013. Crossref

  2. Barrionuevo Paula, Delpino M. Victoria, Pozner Roberto G., Velásquez Lis N., Cassataro Juliana, Giambartolomei Guillermo H., Brucella abortusinduces intracellular retention of MHC-I molecules in human macrophages down-modulating cytotoxic CD8+T cell responses, Cellular Microbiology, 15, 4, 2013. Crossref

  3. Jain Shikha, Afley Prachiti, Kumar Subodh, Immunological responses to recombinant cysteine synthase A of Brucella abortus in BALB/c mice, World Journal of Microbiology and Biotechnology, 29, 5, 2013. Crossref

  4. Gomo Calvin, Musari Shuvai, De Garine-Wichatitsky Michel, Caron Alexandre, Pfukenyi Davies M., Van Heerden Henriette, Detection of <i>Brucella abortus</i> in Chiredzi district in Zimbabwe, Onderstepoort J Vet Res, 79, 1, 2012. Crossref

  5. Jain-Gupta Neeta, Contreras-Rodriguez Araceli, Vemulapalli Ramesh, Witonsky Sharon G., Boyle Stephen M., Sriranganathan Nammalwar, Pluronic P85 enhances the efficacy of outer membrane vesicles as a subunit vaccine againstBrucella melitensischallenge in mice, FEMS Immunology & Medical Microbiology, 66, 3, 2012. Crossref

  6. Hickok Noreen J., Shapiro Irving M., Immobilized antibiotics to prevent orthopaedic implant infections, Advanced Drug Delivery Reviews, 64, 12, 2012. Crossref

  7. Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Hasani Seyed-Shahaboddin, Hadadi-fishani Mehdi, Mirghanizadeh-Bafghi Seyyed-Ali, Asadi-Saghandi Abolghasem, Zare Fateme, Sadeghi-Kalani Behrooz, Ghazali-bina Mehran, Relationship between γ-interferon gene polymorphisms and susceptibility to brucellosis infection, Microbiology and Immunology, 57, 11, 2013. Crossref

  8. Eskandari-Nasab E., Moghadampour M., Asadi-Saghandi A., Kharazi-nejad E., Rezaeifar A., Pourmasoumi H., Levels of Interleukin-(IL)-12p40 are Markedly Increased in Brucellosis Among Patients with SpecificIL-12BGenotypes, Scandinavian Journal of Immunology, 78, 1, 2013. Crossref

  9. Wang Wenjing, Wu Jingbo, Qiao Jun, Weng Yunceng, Zhang Hui, Liao Qingyu, Qiu Jinlang, Chen Chuangfu, Allain Jean-Pierre, Li Chengyao, Evaluation of humoral and cellular immune responses to BP26 and OMP31 epitopes in the attenuated Brucella melitensis vaccinated sheep, Vaccine, 32, 7, 2014. Crossref

  10. Lowry Jake E., Leonhardt Jack A., Yao Chaoqun, Belden E. Lee, Andrews Gerard P., INFECTION OF C57BL/6 MICE BYTRYPANOSOMA MUSCULIMODULATES HOST IMMUNE RESPONSES DURINGBRUCELLA ABORTUSCOCOLONIZATION, Journal of Wildlife Diseases, 50, 1, 2014. Crossref

  11. Jain Shikha, Afley Prachiti, Dohre Sudhir K., Saxena Nandita, Kumar Subodh, Evaluation of immunogenicity and protective efficacy of a plasmid DNA vaccine encoding ribosomal protein L9 of Brucella abortus in BALB/c mice, Vaccine, 32, 35, 2014. Crossref

  12. González-González Edith, García-Hernández Ana Lilia, Flores-Mejía Raúl, López-Santiago Rubén, Moreno-Fierros Leticia, The protoxin Cry1Ac of Bacillus thuringiensis improves the protection conferred by intranasal immunization with Brucella abortus RB51 in a mouse model, Veterinary Microbiology, 175, 2-4, 2015. Crossref

  13. . Nasserin Hashim, . Ali Hassabo, . Sanaa O. Yagoub, Serological Detection of Brucellosis in Cattle and Human, Research Journal of Microbiology, 2, 11, 2007. Crossref

  14. Kumar Sudhir, Kumar Nitesh, Alam Neelima, Gourinath Samudrala, Crystal structure of serine acetyl transferase from Brucella abortus and its complex with coenzyme A, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1844, 10, 2014. Crossref

  15. Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Najibi Habib, Hadadi-Fishani Mehdi, Investigation of CTLA-4 and CD86 gene polymorphisms in Iranian patients with brucellosis infection, Microbiology and Immunology, 58, 2, 2014. Crossref

  16. Alva-Pérez Jorge, Arellano-Reynoso Beatriz, Hernández-Castro Rigoberto, Suárez-Güemes Francisco, TheinvAgene ofBrucella melitensisis involved in intracellular invasion and is required to establish infection in a mouse model, Virulence, 5, 4, 2014. Crossref

  17. Spera Juan M., Comerci Diego J., Ugalde Juan E., Brucella alters the immune response in a prpA-dependent manner, Microbial Pathogenesis, 67-68, 2014. Crossref

  18. Singh Damini, Somani Vikas Kumar, Aggarwal Somya, Bhatnagar Rakesh, PLGA (85:15) nanoparticle based delivery of rL7/L12 ribosomal protein in mice protects against Brucella abortus 544 infection: A promising alternate to traditional adjuvants, Molecular Immunology, 68, 2, 2015. Crossref

  19. Goenka Radhika, Guirnalda Patrick D., Black Samuel J., Baldwin Cynthia L., B Lymphocytes Provide an Infection Niche for Intracellular Bacterium Brucella abortus, The Journal of Infectious Diseases, 206, 1, 2012. Crossref

  20. Singh Damini, Goel Divya, Bhatnagar Rakesh, Recombinant L7/L12 protein entrapping PLGA (poly lactide-co-glycolide) micro particles protect BALB/c mice against the virulent B. abortus 544 infection, Vaccine, 33, 24, 2015. Crossref

  21. Whatmore Adrian M., Current understanding of the genetic diversity of Brucella, an expanding genus of zoonotic pathogens, Infection, Genetics and Evolution, 9, 6, 2009. Crossref

  22. Goel Divya, Bhatnagar Rakesh, Intradermal immunization with outer membrane protein 25 protects Balb/c mice from virulent B. abortus 544, Molecular Immunology, 51, 2, 2012. Crossref

  23. von Bargen Kristine, Gorvel Jean-Pierre, Salcedo Suzana P., Internal affairs: investigating theBrucellaintracellular lifestyle, FEMS Microbiology Reviews, 36, 3, 2012. Crossref

  24. de Figueiredo Paul, Ficht Thomas A., Rice-Ficht Allison, Rossetti Carlos A., Adams L. Garry, Pathogenesis and Immunobiology of Brucellosis, The American Journal of Pathology, 185, 6, 2015. Crossref

  25. Bouhet Sandrine, Lafont Virginie, Billard Elisabeth, Gross Antoine, Dornand Jacques, The IFNγ-induced STAT1-CBP/P300 association, required for a normal response to the cytokine, is disrupted in Brucella-infected macrophages, Microbial Pathogenesis, 46, 2, 2009. Crossref

  26. Parent Michelle A., Goenka Radhika, Murphy Erin, LeVier Kristen, Carreiro Nuno, Golding Basil, Ferguson Gail, Roop R. Martin, Walker Graham C., Baldwin Cynthia L., Brucella abortus bacA mutant induces greater pro-inflammatory cytokines than the wild-type parent strain, Microbes and Infection, 9, 1, 2007. Crossref

  27. Teske Sondra S., Huang Yin, Tamrakar Sushil B., Bartrand Timothy A., Weir Mark H., Haas Charles N., Animal and Human Dose-Response Models for Brucella Species, Risk Analysis, 31, 10, 2011. Crossref

  28. Martirosyan Anna, Moreno Edgardo, Gorvel Jean-Pierre, An evolutionary strategy for a stealthy intracellular Brucella pathogen, Immunological Reviews, 240, 1, 2011. Crossref

  29. Barrionuevo Paula, Delpino M. Victoria, Velásquez Lis N., García Samartino Clara, Coria Lorena M., Ibañez Andrés E., Rodríguez María Eugenia, Cassataro Juliana, Giambartolomei Guillermo H., Brucella abortus inhibits IFN-γ-induced FcγRI expression and FcγRI-restricted phagocytosis via toll-like receptor 2 on human monocytes/macrophages, Microbes and Infection, 13, 3, 2011. Crossref

  30. Proal Amy D., Albert Paul J., Marshall Trevor, Autoimmune disease in the era of the metagenome, Autoimmunity Reviews, 8, 8, 2009. Crossref

  31. Skendros Panagiotis, Pappas Georgios, Boura Panagiota, Cell-mediated immunity in human brucellosis, Microbes and Infection, 13, 2, 2011. Crossref

  32. Dorneles Elaine M.S., Teixeira-Carvalho Andréa, Araújo Márcio S.S., Sriranganathan Nammalwar, Lage Andrey P., Immune response triggered by Brucella abortus following infection or vaccination, Vaccine, 33, 31, 2015. Crossref

  33. Dayan Lior, Deyev Sergei, Palma Lucio, Rozen Nimrod, Long-standing, neglected sacroiliitis with remarked sacro-iliac degenerative changes as a result of Brucella spp. infection, The Spine Journal, 9, 3, 2009. Crossref

  34. Billard Elisabeth, Dornand Jacques, Gross Antoine, VirB type IV secretory system does not contribute toBrucella suis' avoidance of human dendritic cell maturation, FEMS Immunology & Medical Microbiology, 53, 3, 2008. Crossref

  35. Du Zhi-Qiang, Li Xin, Wang Jian-Ying, Immunogenicity Analysis of a Novel Subunit Vaccine Candidate Molecule—Recombinant L7/L12 Ribosomal Protein of Brucella suis, Applied Biochemistry and Biotechnology, 179, 8, 2016. Crossref

  36. Porcine brucellosis (Brucella suis), EFSA Journal, 7, 6, 2009. Crossref

  37. de Almeida Leonardo A., Carvalho Natalia B., Oliveira Fernanda S., Lacerda Thais L. S., Vasconcelos Anilton C., Nogueira Lucas, Bafica Andre, Silva Aristóbolo M., Oliveira Sergio C., Zamboni Dario S., MyD88 and STING Signaling Pathways Are Required for IRF3-Mediated IFN-β Induction in Response to Brucella abortus Infection, PLoS ONE, 6, 8, 2011. Crossref

  38. Miranda Karina Leite, Poester Fernando Padilla, Dorneles Elaine Maria Seles, Resende Thiago Magalhães, Vaz Adil Knackfuss, Ferraz Sandra Maria, Lage Andrey Pereira, Brucella abortus RB51 in milk of vaccinated adult cattle, Acta Tropica, 160, 2016. Crossref

  39. KWON Ae Jeong, MOON Ja Young, KIM Won Kyong, KIM Suk, HUR Jin, Protection efficacy of the <i>Brucella abortus</i> ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models, Journal of Veterinary Medical Science, 78, 10, 2016. Crossref

  40. Velásquez Lis N, Milillo M Ayelén, Delpino M Victoria, Trotta Aldana, Mercogliano M Florencia, Pozner Roberto G, Schillaci Roxana, Elizalde Patricia V, Giambartolomei Guillermo H, Barrionuevo Paula, Inhibition of MHC‐I by Brucella abortus is an early event during infection and involves EGFR pathway , Immunology & Cell Biology, 95, 4, 2017. Crossref

  41. Pasquevich Karina A., Ibañez Andrés E., Coria Lorena M., García Samartino Clara, Estein Silvia M., Zwerdling Astrid, Barrionuevo Paula, Oliveira Fernanda S., Seither Christine, Warzecha Heribert, Oliveira Sergio C., Giambartolomei Guillermo H., Cassataro Juliana, Rodrigues Mauricio Martins, An Oral Vaccine Based on U-Omp19 Induces Protection against B. abortus Mucosal Challenge by Inducing an Adaptive IL-17 Immune Response in Mice, PLoS ONE, 6, 1, 2011. Crossref

  42. Martirosyan Anna, Von Bargen Kristine, Arce Gorvel Vilma, Zhao Weidong, Hanniffy Sean, Bonnardel Johnny, Méresse Stéphane, Gorvel Jean-Pierre, Moreno Edgardo, In Vivo Identification and Characterization of CD4+ Cytotoxic T Cells Induced by Virulent Brucella abortus Infection, PLoS ONE, 8, 12, 2013. Crossref

  43. Skendros Panagiotis, Sarantopoulos Alexandros, Tselios Konstantinos, Boura Panagiota, Chronic Brucellosis Patients Retain Low Frequency of CD4+ T-Lymphocytes Expressing CD25 and CD28 afterEscherichia coliLPS Stimulation of PHA-Cultured PBMCs, Clinical and Developmental Immunology, 2008, 2008. Crossref

  44. Lei Shuangshuang, Zhong Zhijun, Ke Yuehua, Yang Mingjuan, Xu Xiaoyang, Ren Hang, An Chang, Yuan Jiuyun, Yu Jiuxuan, Xu Jie, Qiu Yefeng, Shi Yanchun, Wang Yufei, Peng Guangneng, Chen Zeliang, Deletion of the Small RNA Chaperone Protein Hfq down Regulates Genes Related to Virulence and Confers Protection against Wild-Type Brucella Challenge in Mice, Frontiers in Microbiology, 6, 2016. Crossref

  45. Kim Won K., Moon Ja Y., Kim Suk, Hur Jin, Comparison between Immunization Routes of Live Attenuated Salmonella Typhimurium Strains Expressing BCSP31, Omp3b, and SOD of Brucella abortus in Murine Model, Frontiers in Microbiology, 7, 2016. Crossref

  46. Ahmed Waqas, Zheng Ke, Liu Zheng-Fei, Establishment of Chronic Infection: Brucella's Stealth Strategy, Frontiers in Cellular and Infection Microbiology, 6, 2016. Crossref

  47. Durward Marina, Radhakrishnan Girish, Harms Jerome, Bareiss Claire, Magnani Diogo, Splitter Gary A., Giambartolomei Guillermo H., Active Evasion of CTL Mediated Killing and Low Quality Responding CD8+ T Cells Contribute to Persistence of Brucellosis, PLoS ONE, 7, 4, 2012. Crossref

  48. González David, Grilló María-Jesús, De Miguel María-Jesús, Ali Tara, Arce-Gorvel Vilma, Delrue Rose-May, Conde-Álvarez Raquel, Muñoz Pilar, López-Goñi Ignacio, Iriarte Maite, Marín Clara-M., Weintraub Andrej, Widmalm Göran, Zygmunt Michel, Letesson Jean-Jacques, Gorvel Jean-Pierre, Blasco José-María, Moriyón Ignacio, Nielsen Kirsten, Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export, PLoS ONE, 3, 7, 2008. Crossref

  49. Raj Sugandha, Saxena Hari Mohan, Singh Sikh Tejinder, Titers of Anti-Brucella Antibodies by Enzyme Linked Immunosorbant Assay in Vaccinated and Unvaccinated Brucellosis Infected Cattle, Open Journal of Veterinary Medicine, 07, 10, 2017. Crossref

  50. Zhao Yun, Hanniffy Sean, Arce-Gorvel Vilma, Conde-Alvarez Raquel, Oh SangKon, Moriyón Ignacio, Mémet Sylvie, Gorvel Jean-Pierre, Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo, Virulence, 9, 1, 2018. Crossref

  51. Li Jinfeng, Hu Feihuan, Chen Shouyi, Luo Peifang, He Zuoping, Wang Wenjing, Allain Jean-Pierre, Li Chengyao, Characterization of novel Omp31 antigenic epitopes of Brucella melitensis by monoclonal antibodies, BMC Microbiology, 17, 1, 2017. Crossref

  52. Arias Maykel A., Santiago Llipsy, Costas-Ramon Santiago, Jaime-Sánchez Paula, Freudenberg Marina, Jiménez De Bagüés Maria P., Pardo Julián, Toll-Like Receptors 2 and 4 Cooperate in the Control of the Emerging Pathogen Brucella microti, Frontiers in Cellular and Infection Microbiology, 6, 2017. Crossref

  53. Kim Won Kyong, Moon Ja Young, Cho Jeong Sang, Hur Jin, Protective efficacy by various doses of a new brucellosis vaccine candidate based on Salmonella strains expressing Brucella abortus BSCP31, Omp3b and superoxide dismutase against brucellosis in murine model, Pathogens and Disease, 75, 7, 2017. Crossref

  54. Covert Jill, Mathison Angela J., Eskra Linda, Banai Menachem, Splitter Gary, Brucella melitensis, B. neotomae and B. ovis Elicit Common and Distinctive Macrophage Defense Transcriptional Responses, Experimental Biology and Medicine, 234, 12, 2009. Crossref

  55. Milillo M. Ayelén, Velásquez Lis N., Trotta Aldana, Delpino M. Victoria, Marinho Fábio V., Balboa Luciana, Vermeulen Mónica, Espindola Sonia L., Rodriguez-Rodrigues Nahuel, Fernández Gabriela C., Oliveira Sergio Costa, Giambartolomei Guillermo H., Barrionuevo Paula, Coombes Brian K, B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway, PLOS Pathogens, 13, 8, 2017. Crossref

  56. Lowry Jake E., Isaak Dale D., Leonhardt Jack A., Vernati Giulia, Pate Jessie C., Andrews Gerard P., Lu Shan, Vaccination with Brucella abortus Recombinant In Vivo-Induced Antigens Reduces Bacterial Load and Promotes Clearance in a Mouse Model for Infection, PLoS ONE, 6, 3, 2011. Crossref

  57. Barquero-Calvo Elías, Martirosyan Anna, Ordoñez-Rueda Diana, Arce-Gorvel Vilma, Alfaro-Alarcón Alejandro, Lepidi Hubert, Malissen Bernard, Malissen Marie, Gorvel Jean-Pierre, Moreno Edgardo, Tsolis Renée M., Neutrophils Exert a Suppressive Effect on Th1 Responses to Intracellular Pathogen Brucella abortus, PLoS Pathogens, 9, 2, 2013. Crossref

  58. Roop II R. Martin, Elhassanny Ahmed E., Almirón Marta A., Anderson Eric S., Atkinson Xavier J., Iron, in Metals and the Biology and Virulence of Brucella, 2017. Crossref

  59. Osman Abdinasir Yusuf, Saharee Abdul Aziz, Jesse Faez Firdaus, Kadir Arifah Abdul, Comparative study of immunopathophysiological responses induced by B. melitensis and its lipopolysaccharide in mouse model infected via intranasal route of exposure, Microbial Pathogenesis, 110, 2017. Crossref

  60. Gómez Leonardo, Llanos Javiera, Escalona Emilia, Sáez Darwin, Álvarez Francisco, Molina Raúl, Flores Manuel, Oñate Angel, Multivalent Fusion DNA Vaccine against Brucella abortus, BioMed Research International, 2017, 2017. Crossref

  61. Cherwonogrodzky John W., Barabé Nicole D., Grigat Michelle L., Lee William E., Poirier Robert T., Jager Scott J., Berger Bradley J., Pasetti M. F., Thermostable Cross-Protective Subunit Vaccine against Brucella Species, Clinical and Vaccine Immunology, 21, 12, 2014. Crossref

  62. Osman Abdinasir Yusuf, Saharee Abdul Aziz, Jesse Faez Firdaus, Kadir Arifah Abdul, Comparative experimental study of Brucella melitensis and its lipopolysaccharide in mouse model infected via subcutaneous route of exposure, Microbial Pathogenesis, 116, 2018. Crossref

  63. Zheng Rongjiong, Xie Songsong, Niyazi Shaniya, Lu Xiaobo, Sun Lihua, Zhou Yan, Zhang Yuexin, Wang Kai, Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis, Journal of Immunology Research, 2018, 2018. Crossref

  64. Budak Ferah, Bal Salih Haldun, Tezcan Gulcin, Akalın Emin Halis, Yılmaz Abdullah, Hız Pınar, Oral Haluk Barbaros, Roop Roy Martin, The microRNA expression signature of CD4+ T cells in the transition of brucellosis into chronicity, PLOS ONE, 13, 6, 2018. Crossref

  65. Cotterill Gavin G., Cross Paul C., Cole Eric K., Fuda Rebecca K., Rogerson Jared D., Scurlock Brandon M., du Toit Johan T., Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics, Philosophical Transactions of the Royal Society B: Biological Sciences, 373, 1745, 2018. Crossref

  66. Miraglia María C., Rodriguez Ana M., Barrionuevo Paula, Rodriguez Julia, Kim Kwang S., Dennis Vida A., Delpino M. Victoria, Giambartolomei Guillermo H., Brucella abortus Traverses Brain Microvascular Endothelial Cells Using Infected Monocytes as a Trojan Horse, Frontiers in Cellular and Infection Microbiology, 8, 2018. Crossref

  67. Kim Won Kyong, Moon Ja Young, Cho Jeong Sang, Akanda Md Rashedunnabi, Park Byung Yong, Kug Eo Seong, Park Sang Youel, Lee John Hwa, Hur Jin, Brucella abortus lysed cells using GI24 induce robust immune response and provide effective protection in Beagles, Pathogens and Disease, 76, 1, 2018. Crossref

  68. Pollak Cora N., Wanke María Magdalena, Estein Silvia M., Delpino M. Victoria, Monachesi Norma E., Comercio Elida A., Fossati Carlos A., Baldi Pablo C., Staats H. F., Immunization with Brucella VirB Proteins Reduces Organ Colonization in Mice through a Th1-Type Immune Response and Elicits a Similar Immune Response in Dogs, Clinical and Vaccine Immunology, 22, 3, 2015. Crossref

  69. Gheibi Azam, Khanahmad Hossein, Kashfi Khosrow, Sarmadi Mahdieh, Khorramizadeh Mohammad Reza, Development of new generation of vaccines for Brucella abortus, Heliyon, 4, 12, 2018. Crossref

  70. Pasquevich Karina A., García Samartino Clara, Coria Lorena M., Estein Silvia M., Zwerdling Astrid, Ibañez Andrés E., Barrionuevo Paula, Oliveira Fernanda Souza de, Carvalho Natalia Barbosa, Borkowski Julia, Oliveira Sergio Costa, Warzecha Heribert, Giambartolomei Guillermo H., Cassataro Juliana, The Protein Moiety of Brucella abortus Outer Membrane Protein 16 Is a New Bacterial Pathogen-Associated Molecular Pattern That Activates Dendritic Cells In Vivo, Induces a Th1 Immune Response, and Is a Promising Self-Adjuvanting Vaccine against Systemic and Oral Acquired Brucellosis, The Journal of Immunology, 184, 9, 2010. Crossref

  71. KIM Won Kyong, MOON Ja Young, CHO Jeong Sang, PARK Byung Yong, HUR Jin, Protective efficacy of a canine brucellosis vaccine candidate based on live attenuated <i>Salmonella</i> expressing recombinant <i>Brucella</i> BCSP31, Omp3b and SOD proteins in Beagles, Journal of Veterinary Medical Science, 80, 9, 2018. Crossref

  72. Olsen Steven C., Boggiatto Paola, Nol Pauline, Samartino Luis, Brucellosis, in Diseases of Swine, 2019. Crossref

  73. Proal Amy D., Albert Paul J., Marshall Trevor G., Autoimmune Disease and the Human Metagenome, in Metagenomics of the Human Body, 2011. Crossref

  74. Muñoz González Florencia, Sycz Gabriela, Alonso Paiva Iván M., Linke Dirk, Zorreguieta Angeles, Baldi Pablo C., Ferrero Mariana C., The BtaF Adhesin Is Necessary for Full Virulence During Respiratory Infection by Brucella suis and Is a Novel Immunogen for Nasal Vaccination Against Brucella Infection, Frontiers in Immunology, 10, 2019. Crossref

  75. Dubrovina V. I., Konovalova Zh. A., Yastremskaya K. U., Barannikova N. L., Tokareva L. E., Balakhonov S. V., The Mechanisms of CellularImmune Response in Brucellosis, Epidemiology and Vaccine Prevention, 15, 6, 2016. Crossref

  76. Kumar D. Ravi, Sivalingam Jayakumar, Mishra Shailendra K., Kumar Anshuman, Vineeth M. R., Chaudhuri Pallab, Kataria R. S., Niranjan S. K., Differential expression of cytokines in PBMC ofBos indicusandBos taurus×Bos indicuscattle due toBrucella abortusS19 antigen, Animal Biotechnology, 31, 2, 2020. Crossref

  77. Hwang Eunmi, Kim Gye Won, Song Ki Duk, Lee Hak-Kyo, Kim Sung-Jo, The enhancing effect of Acanthopanax sessiliflorus fruit extract on the antibacterial activity of porcine alveolar 3D4/31 macrophages via nuclear factor kappa B1 and lipid metabolism regulation, Asian-Australasian Journal of Animal Sciences, 32, 11, 2019. Crossref

  78. Avila-Calderón Eric Daniel, Flores-Romo Leopoldo, Sharon Witonsky, Donis-Maturano Luis, Becerril-García Miguel Angel, Arreola Ma. Guadalupe Aguilera, Reynoso Beatriz Arellano, Güemes Francisco Suarez, Contreras-Rodríguez Araceli, Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen, Folia Microbiologica, 65, 1, 2020. Crossref

  79. Rodríguez Ana M., Delpino M. Victoria, Miraglia María Cruz, Giambartolomei Guillermo H., Immune Mediators of Pathology in Neurobrucellosis: From Blood to Central Nervous System, Neuroscience, 410, 2019. Crossref

  80. Milillo M. Ayelén, Trotta Aldana, Serafino Agustina, Marin Franco José Luis, Marinho Fábio V., Alcain Julieta, Genoula Melanie, Balboa Luciana, Oliveira Sergio Costa, Giambartolomei Guillermo H., Barrionuevo Paula, Bacterial RNA Contributes to the Down-Modulation of MHC-II Expression on Monocytes/Macrophages Diminishing CD4+ T Cell Responses, Frontiers in Immunology, 10, 2019. Crossref

  81. Macedo Gilson Costa, Magnani Diogo Matos, Carvalho Natalia Barbosa, Bruna-Romero Oscar, Gazzinelli Ricardo T., Oliveira Sergio Costa, Central Role of MyD88-Dependent Dendritic Cell Maturation and Proinflammatory Cytokine Production to ControlBrucella abortusInfection, The Journal of Immunology, 180, 2, 2008. Crossref

  82. Barrionuevo Paula, Giambartolomei Guillermo H., Inhibition of antigen presentation by Brucella: many more than many ways, Microbes and Infection, 21, 3-4, 2019. Crossref

  83. Qiu Yuanhao, Lu Chunbo, Chen Peng, Sun Feifei, Wang Dongdong, Wang Zhaojie, Hou Chunyan, Mu Haibo, Duan Jinyou, Synergistic clearance of intracellular pathogens by hyaluronan-streptomycin micelles encapsulated with rapamycin, Carbohydrate Polymers, 210, 2019. Crossref

  84. Priyanka , Shringi Brij Nandan, Choudhary Om Prakash, Kashyap Sudhir Kumar, Cytokines in brucellosis: biological rhythm at the interface of innate and adaptive immunity, Biological Rhythm Research, 52, 7, 2021. Crossref

  85. Kauffman Lin K., Petersen Christine A., Canine Brucellosis, Veterinary Clinics of North America: Small Animal Practice, 49, 4, 2019. Crossref

  86. Thakur Aneesh, Mikkelsen Heidi, Jungersen Gregers, Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies, Journal of Immunology Research, 2019, 2019. Crossref

  87. Wang Hongbin, Hoffman Carol, Yang Xinghong, Clapp Beata, Pascual David W., Zamboni Dario S., Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection, PLOS Pathogens, 16, 1, 2020. Crossref

  88. Eckstein Camila, Mol Juliana P. S., Costa Fabíola B., Nunes Philipe P., Lima Pâmela A., Melo Marília M., Carvalho Thaynara P., Santos Daniel O., Silva Monique F., Carvalho Tatiane F., Costa Luciana F., Melo Júnior Otoni A. O., Giunchette Rodolfo C., Paixão Tatiane A., Santos Renato L., Roop Roy Martin, Brucella ovis mutant in ABC transporter protects against Brucella canis infection in mice and it is safe for dogs, PLOS ONE, 15, 4, 2020. Crossref

  89. Forte Giusi Irma, Scola Letizia, Misiano Gabriella, Milano Salvatore, Mansueto Pasquale, Vitale Giustina, Bellanca Fiamma, Sanacore Maria, Vaccarino Loredana, Rini Giovan Battista, Caruso Calogero, Cillari Enrico, Lio Domenico, Mansueto Serafino, Relevance of Gamma Interferon, Tumor Necrosis Factor Alpha, and Interleukin-10 Gene Polymorphisms to Susceptibility to Mediterranean Spotted Fever, Clinical and Vaccine Immunology, 16, 6, 2009. Crossref

  90. Carvalho Tatiane F., Haddad João Paulo A., Paixão Tatiane A., Santos Renato L., Meta-analysis of brucellosis vaccinology in natural hosts, Pesquisa Veterinária Brasileira, 40, 8, 2020. Crossref

  91. Daggett Juliane, Rogers Alexandra, Harms Jerome, Splitter Gary A., Durward-Diioia Marina, Hepatic and splenic immune response during acute vs. chronic Brucella melitensis infection using in situ microscopy, Comparative Immunology, Microbiology and Infectious Diseases, 73, 2020. Crossref

  92. Mirzaei Rasoul, Sholeh Mohammad, Jalalifar Saba, Zafari Ehsan, Kazemi Sima, Rasouli-Saravani Ashkan, Karampoor Sajad, Yousefimashouf Rasoul, Immunometabolism in human brucellosis: An emerging field of investigation, Microbial Pathogenesis, 158, 2021. Crossref

  93. Magnani Diogo M., Lyons Elizabeth T., Forde Toni S., Shekhani Mohammed T., Adarichev Vyacheslav A., Splitter Gary A., Osteoarticular tissue infection and development of skeletal pathology in murine brucellosis, Disease Models & Mechanisms, 2013. Crossref

  94. Martirosyan Anna, Gorvel Jean-Pierre, Brucella evasion of adaptive immunity, Future Microbiology, 8, 2, 2013. Crossref

  95. Grilló María-Jesús, Blasco José María, Gorvel Jean Pierre, Moriyón Ignacio, Moreno Edgardo, What have we learned from brucellosis in the mouse model?, Veterinary Research, 43, 1, 2012. Crossref

  96. Al-Anazi KA, Al-Jasser AM, Brucellosis in Immunocompromised Hosts, Archives of Organ Transplantation, 1, 1, 2016. Crossref

  97. Stranahan Lauren W., Arenas-Gamboa Angela M., When the Going Gets Rough: The Significance of Brucella Lipopolysaccharide Phenotype in Host–Pathogen Interactions, Frontiers in Microbiology, 12, 2021. Crossref

  98. Leya Mwense, Kim Won Kyong, Ochirkhuyag Enkhsaikhan, Yu Eun-Chae, Kim Young-Jee, Yeo Yoonhwan, Yang Myeon-Sik, Han Sang-Seop, Lee John Hwa, Tark Dongseob, Hur Jin, Kim Bumseok, Protective efficacy of attenuated Salmonella Typhimurium strain expressing BLS, Omp19, PrpA, or SOD of Brucella abortus in goats, Journal of Veterinary Science, 22, 2, 2021. Crossref

  99. Castillo-Zeledón Amanda, Ruiz-Villalobos Nazareth, Altamirano-Silva Pamela, Chacón-Díaz Carlos, Barquero-Calvo Elías, Chaves-Olarte Esteban, Guzmán-Verri Caterina, Roop Roy Martin, A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence, PLOS ONE, 16, 8, 2021. Crossref

  100. Harms Jerome S., Khan Mike, Hall Cherisse, Splitter Gary A., Homan E. Jane, Bremel Robert D., Smith Judith A., Palmer Guy H., Brucella Peptide Cross-Reactive Major Histocompatibility Complex Class I Presentation Activates SIINFEKL-Specific T Cell Receptor-Expressing T Cells, Infection and Immunity, 86, 7, 2018. Crossref

  101. Chacón-Díaz Carlos, Altamirano-Silva Pamela, González-Espinoza Gabriela, Medina María-Concepción, Alfaro-Alarcón Alejandro, Bouza-Mora Laura, Jiménez-Rojas César, Wong Melissa, Barquero-Calvo Elías, Rojas Norman, Guzmán-Verri Caterina, Moreno Edgardo, Chaves-Olarte Esteban, Roy C. R., Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts, Infection and Immunity, 83, 12, 2015. Crossref

  102. Elrashedy Alyaa, Gaafar Mohamed, Mousa Walid, Nayel Mohamed, Salama Akram, Zaghawa Ahmed, Elsify Ahmed, Dawood Ali S., Immune response and recent advances in diagnosis and control of brucellosis, German Journal of Veterinary Research, 2, 1, 2022. Crossref

  103. Zhu Yongzhang, Shi Li, Zeng Yige, Piao Dongri, Xie Yingbo, Du Juan, Gao Meng, Gao Wei, Tian Junli, Yue Jun, Li Min, Guo XiaoKui, Yao Yufeng, Kang YaoXia, Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China, Infectious Diseases of Poverty, 11, 1, 2022. Crossref

  104. Billard Elisabeth, Dornand Jacques, Gross Antoine, Brucella suis Prevents Human Dendritic Cell Maturation and Antigen Presentation through Regulation of Tumor Necrosis Factor Alpha Secretion , Infection and Immunity, 75, 10, 2007. Crossref

  105. Billard Elisabeth, Dornand Jacques, Gross Antoine, Interaction of Brucella suis and Brucella abortus Rough Strains with Human Dendritic Cells , Infection and Immunity, 75, 12, 2007. Crossref

  106. Roop R. Martin, Barton Ian S., Hopersberger Dariel, Martin Daniel W., Uncovering the Hidden Credentials of Brucella Virulence , Microbiology and Molecular Biology Reviews, 85, 1, 2021. Crossref

  107. Lou Lixin, Bao Wanguo, Liu Xianjun, Song Hongxiao, Wang Yang, Zhang Kaiyu, Gao Wenjing, Li Haijun, Tu Zhengkun, Wang Shaofeng, Tang Yi-Wei, An Autoimmune Disease-Associated Risk Variant in the TNFAIP3 Gene Plays a Protective Role in Brucellosis That Is Mediated by the NF-κB Signaling Pathway , Journal of Clinical Microbiology, 56, 4, 2018. Crossref

  108. Pasquevich Karina A., Estein Silvia M., Samartino Clara García, Zwerdling Astrid, Coria Lorena M., Barrionuevo Paula, Fossati Carlos A., Giambartolomei Guillermo H., Cassataro Juliana, Immunization with Recombinant Brucella Species Outer Membrane Protein Omp16 or Omp19 in Adjuvant Induces Specific CD4 + and CD8 + T Cells as Well as Systemic and Oral Protection against Brucella abortus Infection , Infection and Immunity, 77, 1, 2009. Crossref

  109. Vitry Marie-Alice, De Trez Carl, Goriely Stanislas, Dumoutier Laure, Akira Shizuo, Ryffel Bernhard, Carlier Yves, Letesson Jean-Jacques, Muraille Eric, Morrison R. P., Crucial Role of Gamma Interferon-Producing CD4 + Th1 Cells but Dispensable Function of CD8 + T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice , Infection and Immunity, 80, 12, 2012. Crossref

  110. Durward Marina A., Harms Jerome, Magnani Diogo M., Eskra Linda, Splitter Gary A., Discordant Brucella melitensis Antigens Yield Cognate CD8 + T Cells In Vivo , Infection and Immunity, 78, 1, 2010. Crossref

  111. Moran María Celeste, Dominguez María Paula, Bence Angel Ricardo, Rodriguez Marcelo Gastón, Goldbaum Fernando Alberto, Zylberman Vanesa, Paola Pardo Romina, Lupi Giuliana, Marcipar Ivan Sergio, Lützelschwab Claudia María, Estein Silvia Marcela, Evaluation of the efficacy of polymeric antigen BLSOmp31 formulated in a new cage-like particle adjuvant (ISPA) administered by parenteral or mucosal routes against Brucella ovis in BALB/c mice, Research in Veterinary Science, 145, 2022. Crossref

  112. Moreno Edgardo, Barquero-Calvo Elías, The Role of Neutrophils in Brucellosis, Microbiology and Molecular Biology Reviews, 84, 4, 2020. Crossref

  113. Jiménez de Bagüés María P., de Martino Alba, Quintana Juan F., Alcaraz Ana, Pardo Julián, Blancke S. R., Course of Infection with the Emergent Pathogen Brucella microti in Immunocompromised Mice, Infection and Immunity, 79, 10, 2011. Crossref

  114. Gentilini María Virginia, Velásquez Lis Noelia, Barrionuevo Paula, Arriola Benitez Paula Constanza, Giambartolomei Guillermo Hernán, Delpino María Victoria, Camilli A., Adrenal Steroids Modulate the Immune Response during Brucella abortus Infection by a Mechanism That Depends on the Regulation of Cytokine Production, Infection and Immunity, 83, 5, 2015. Crossref

  115. Durward-Diioia Marina, Harms Jerome, Khan Mike, Hall Cherisse, Smith Judith A., Splitter Gary A., Bäumler A. J., CD8 + T Cell Exhaustion, Suppressed Gamma Interferon Production, and Delayed Memory Response Induced by Chronic Brucella melitensis Infection , Infection and Immunity, 83, 12, 2015. Crossref

  116. Poveda-Urkixo Irati, Ramírez Gustavo A., Grilló María-Jesús, Kinetics of Placental Infection by Different Smooth Brucella Strains in Mice, Pathogens, 11, 3, 2022. Crossref

  117. Mena-Bueno Sara, Poveda-Urkixo Irati, Irazoki Oihane, Palacios Leyre, Cava Felipe, Zabalza-Baranguá Ana, Grilló María Jesús, Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties, Frontiers in Microbiology, 13, 2022. Crossref

  118. Stranahan Lauren W., Garcia-Gonzalez Daniel G., Hensel Martha E., Arenas-Gamboa Angela M., Primary and memory immune responses against rough Brucella canis are less robust compared to smooth B. abortus and B. melitensis following intratracheal infection in mice, Frontiers in Immunology, 13, 2022. Crossref

  119. Su Xiao, Zhao Shigang, Song Yijun, Expression of NLRP3 and AIM2 inflammasome in Peripheral blood in Chinese patients with acute and chronic brucellosis, Scientific Reports, 12, 1, 2022. Crossref

将发表的论文

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain