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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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The Nature of Selection on the Major Histocompatibility Complex

卷 37, 册 2-6, 2017, pp. 75-125
DOI: 10.1615/CritRevImmunol.v37.i2-6.10
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摘要

Only natural selection can account for the extreme genetic diversity of genes of the major histocompatibility complex (MHC). Although the structure and function of classic MHC genes is well understood at the molecular and cellular levels, there is controversy about how MHC diversity is selectively maintained. The diversifying selection can be driven by pathogen interactions and inbreeding avoidance mechanisms. Pathogen-driven selection can maintain MHC polymorphism based on heterozygote advantage or frequency-dependent selection due to pathogen evasion of MHC-dependent immune recognition. Empirical evidence demonstrates that specific MHC haplotypes are resistant to certain infectious agents, while susceptible to others. These data are consistent with both heterozygote advantage and frequency-dependent models. Additional research is needed to discriminate between these mechanisms. Infectious agents can precipitate autoimmunity and can potentially contribute to MHC diversity through molecular mimicry and by favoring immunodominance. MHC-dependent abortion and mate choice, based on olfaction, can also maintain MHC diversity and probably functions both to avoid genome-wide inbreeding and produce MHC-heterozygous offspring with increased immune responsiveness. Although this diverse set of hypotheses are often treated as competing alternatives, we believe that they all fit into a coherent, internally consistent thesis. It is likely that at least in some species, all of these mechanisms operate, leading to the extreme diversification found in MHC genes.

对本文的引用
  1. Wei Jiajie, Yewdell Jonathan W., Flu DRiPs in MHC Class I Immunosurveillance, Virologica Sinica, 34, 2, 2019. Crossref

  2. Nogales Aitor, L. DeDiego Marta, Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans, Pathogens, 8, 4, 2019. Crossref

  3. Havlíček Jan, Winternitz Jamie, Roberts S. Craig, Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons, Philosophical Transactions of the Royal Society B: Biological Sciences, 375, 1800, 2020. Crossref

  4. Foo Yong Zhi, Simmons Leigh W., Perrett David I., Holt Patrick G., Eastwood Peter R., Rhodes Gillian, Immune function during early adolescence positively predicts adult facial sexual dimorphism in both men and women, Evolution and Human Behavior, 41, 3, 2020. Crossref

  5. Ebert Dieter, Fields Peter D., Host–parasite co-evolution and its genomic signature, Nature Reviews Genetics, 21, 12, 2020. Crossref

  6. Holmes Jennifer C., Scholl Elizabeth H., Dickey Allison N., Hess Paul R., High-resolution characterization of the structural features and genetic variation of six feline leukocyte antigen class I loci via single molecule, real-time (SMRT) sequencing, Immunogenetics, 73, 5, 2021. Crossref

  7. Gong Ying, Guo Yi, He Yong-Meng, Yuan Ying, Yang Bai-Gao, Duan Xing-Hai, Liu Cheng-Li, Zhang Jia-Hua, Hong Qiong-Hua, Ma Yue-Hui, Na Ri-Su, Han Yan-Guo, Zeng Yan, Huang Yong-Fu, Zhao Yong-Ju, Zhao Zhong-Quan, E. Guangxin, Comparative analysis of the genetic diversity of the neutral microsatellite loci and second exon of the goat MHC-DQB1 gene, Animal Biotechnology, 2021. Crossref

  8. Migliorini Filippo, Torsiello Ernesto, Spiezia Filippo, Oliva Francesco, Tingart Markus, Maffulli Nicola, Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature, European Journal of Medical Research, 26, 1, 2021. Crossref

  9. Pohjoismäki Jaakko L. O., Michell Craig, Levänen Riikka, Smith Steve, Hybridization with mountain hares increases the functional allelic repertoire in brown hares, Scientific Reports, 11, 1, 2021. Crossref

  10. Wang Xinwen, Wang Liangming, Xu Weifeng, Wang Xinwu, Ke Dianshan, Lin Jinluan, Lin Wanzun, Bai Xiaochun, Classification of Osteosarcoma Based on Immunogenomic Profiling, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  11. Kaufman Jim, The avian major histocompatibility complex, in Avian Immunology, 2022. Crossref

  12. Jennings Sarah L., Hoover Brian A., Wa Sin Simon Yung, Ebeler Susan E., Feather chemicals contain information about the major histocompatibility complex in a highly scented seabird, Proceedings of the Royal Society B: Biological Sciences, 289, 1975, 2022. Crossref

  13. Mancilla-Morales Misael Daniel, Velarde Enriqueta, Contreras-Rodríguez Araceli, Gómez-Lunar Zulema, Rosas-Rodríguez Jesús A., Heras Joseph, Soñanez-Organis José G., Ruiz Enrico A., Characterization, Selection, and Trans-Species Polymorphism in the MHC Class II of Heermann’s Gull (Charadriiformes), Genes, 13, 5, 2022. Crossref

  14. Ament-Velásquez S. Lorena, Vogan Aaron A., Granger-Farbos Alexandra, Bastiaans Eric, Martinossi-Allibert Ivain, Saupe Sven J., de Groot Suzette, Lascoux Martin, Debets Alfons J. M., Clavé Corinne, Johannesson Hanna, Allorecognition genes drive reproductive isolation in Podospora anserina, Nature Ecology & Evolution, 6, 7, 2022. Crossref

  15. Khan Taushif, Rahman Mahbuba, Ahmed Ikhlak, Al Ali Fatima, Jithesh Puthen Veettil, Marr Nico, Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens, Frontiers in Immunology, 13, 2022. Crossref

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