图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.v29.i2.30
pages 131-154

Viral Mechanisms Involved in the Transcriptional CBP/р300 Regulation of Inflammatory and Immune Responses

Yolanda Revilla
Centro de Biologia Molecular "Severo Ochoa," (CSIC-UAM) Universidad Autonoma de Madrid, 28049 Madrid, Spain
Aitor G. Granja
Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, UK

ABSTRACT

The transcriptional coactivators CREB-binding protein (СВР) and р300 regulate inducible transcription in multiple cellular processes and during the establishment of inflammatory and immune response. These closely related transcriptional coactivators arc able to modulate the transcription of specific genes, modify chromatin structure, and influence cell-cycle progression. Several viruses have been shown to interfere with CREB-binding protein/р300 function, modulating their transcriptional activity. During a viral infection, reprogramming of the host cell gene expression pattern is required to establish an adequate antiviral response and, thus, many viruses encode proteins that can influence or interfere with cellular signals to evade inflammation and immune response. The mechanism of transcriptional regulation by coactivator proteins, including р300/CBP, has been the focus of intense study. As a part of this, some of the molecular instruments developed by viruses to counteract the host response and their role in the regulation of inflammation and immune response are summarized in this review.

键词: CBP/p300, NF-κ, В, , NFAT, COX-2, TNF-α, , iNOS, A238L

Articles with similar content:

Immune Mechanisms of Allergic Airway Disease: Regulation by Transcription Factors
Critical Reviews™ in Immunology, Vol.27, 2007, issue 6
Atsushi Onodera, Masakatsu Yamashita, Toshinori Nakayama
The Nuclear Matrix as a Target for Viral and Cellular Oncogenes
Critical Reviews™ in Eukaryotic Gene Expression, Vol.10, 2000, issue 1
Wolfgang Deppert
The Route to HPV-Associated Neoplastic Transformation: A Review of the Literature
Critical Reviews™ in Eukaryotic Gene Expression, Vol.26, 2016, issue 1
Nedime Serakinci, Pinar Tulay
Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF Complex in B Cells
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Osamu Takeuchi, Sarang Tartey
Induction and Function of IFNβ During Viral and Bacterial Infection
Critical Reviews™ in Immunology, Vol.31, 2011, issue 6
Uma Nagarajan