每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
The Role of CARMA1 in T Cells
摘要
Caspase recruitment domain-containing membrane-associated guanylate kinase protein-1 (CARMA1), a member of the membrane associated guanylate kinase (MAGUK) family of kinases, is essential for T lymphocyte activation and proliferation via T-cell receptor (TCR) mediated NF-κB activation. Recent studies suggest a broader role for CARMA1 regulating other T-cell functions as well as a role in non-TCR–mediated signaling pathways important for lymphocyte development and functions. In addition, CARMA1 has been shown to be an important component in the pathogenesis of several human diseases. Thus, comprehensively defining its mechanisms of action and regulation could reveal novel therapeutic targets for T-cell–mediated diseases and lymphoproliferative disorders.
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Wang Wenbin, Wei Qiaolin, Hao Qiqi, Zhang Yajie, Li Yongshan, Bi Youkun, Jin Zhongyuan, Liu Haijin, Liu Xuelan, Yang Zengqi, Xiao Sa, Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts, Frontiers in Microbiology, 12, 2021. Crossref
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Schimmack Gisela, Eitelhuber Andrea C, Vincendeau Michelle, Demski Katrin, Shinohara Hisaaki, Kurosaki Tomohiro, Krappmann Daniel, AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation, Cell Communication and Signaling, 12, 1, 2014. Crossref
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Giussani Paola, Prinetti Alessandro, Tringali Cristina, The Role of Sphingolipids in Cancer Immunotherapy, International Journal of Molecular Sciences, 22, 12, 2021. Crossref
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