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ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Mechanisms of Lipid Antigen Presentation by CD1

卷 19, 册 1, 1999, 15 pages
DOI: 10.1615/CritRevImmunol.v19.i1.20
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摘要

CDl is a family of cell surface glycoproteins that are related in structure and evolutionary origin to the major histocompatibility complex (MHC)-encoded antigen-presenting molecules. In contrast to MHC-encoded antigen-presenting molecules, CDl binds and presents lipid and glycolipid antigens for specific recog¬nition by T cell antigen receptors. Recent work shows that several CDl family members colocalize with MHC class II proteins within the endocytic system of antigen-presenting cells. Detailed studies of the intracellular trafficking of CDl proteins reveal new mechanisms controlling delivery of antigen-presenting molecules to particular compartments within cells. The combination of overlapping yet distinct trafficking routes for the various CDl family members, combined with emerging information on the heterogeneity of CDl-presented lipid antigens, suggest a model whereby different members of the CDl family could present antigens that occur in various cellular compartments. Furthermore, the CDl family as a group may present antigens from pathogens that are not normally accessible to or efficiently surveyed by the MHC Class I or II systems. The discovery of this third pathway for antigen presentation, together with the appreciation of a previously unrecognized universe of nonpeptide lipid antigens for T cell responses, are likely to have broad implications for our understanding of the cell-mediated immune response and its role in health and disease.

对本文的引用
  1. Bobryshev Yuri V., Dendritic cells in atherosclerosis: current status of the problem and clinical relevance, European Heart Journal, 26, 17, 2005. Crossref

  2. Dascher Christopher C., Hiromatsu Kenji, Xiong Xiaowei, Sugita Masahiko, Buhlmann Janet E., Dodge Ingrid L., Lee Stella Y., Roura-Mir Carme, Watts Gerald F., Roy Christopher J., Behar Samuel M., Clemens Daniel L., Porcelli Steve A., Brenner Michael B., Conservation of CD1 Intracellular Trafficking Patterns Between Mammalian Species, The Journal of Immunology, 169, 12, 2002. Crossref

  3. Geho David H., Fayen John D., Jackman Robin M., Moody D. Branch, Porcelli Steven A., Tykocinski Mark L., Glycosyl-Phosphatidylinositol Reanchoring Unmasks Distinct Antigen-Presenting Pathways for CD1b and CD1c, The Journal of Immunology, 165, 3, 2000. Crossref

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