每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Ly-49 Receptors and Their Functions
摘要
Ly-49 receptors are lectin-like type II transmembrane disulfide-bonded homodimers expressed on natural killer (NK) cells and some T-cell subsets. Cell-mediated cytotoxicity and release of cytokines/chemokines are functions regulated by Ly-49 recognition of class I major histocompatibility complex proteins (MHC-I) or virus-encoded MHC-like product(s). Here we examine diversity and conservation found within the Ly-49 gene family and explore the importance of polymorphism in Ly-49 receptor expression, specificity, and function. Several parallels are evident between Ly-49 receptors in rodents and killer Ig-related (KIR) receptors in humans, including receptor gene amplification and diversification, expression patterns, MHC-I specificity, shared signaling, and ultimate effects on NK-cell functions. These similarities suggest that insights gained in defining Ly-49 receptor functions in small animal models could have direct relevance to existing clinical challenges where there may be opportunities to manipulate human NK cells and KIR receptors for therapeutic benefit.
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Barber Melissa A., Zhang Tong, Gagne Bethany A., Van Ginderachter Jo A., De Baetselier Patrick, Sentman Charles L., Ly49G2 receptor blockade reduces tumor burden in a leukemia model but not in a solid tumor model, Cancer Immunology, Immunotherapy, 57, 5, 2008. Crossref
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MacFarlane Alexander W., Yamazaki Tetsuo, Fang Min, Sigal Luis J., Kurosaki Tomohiro, Campbell Kerry S., Enhanced NK-cell development and function in BCAP-deficient mice, Blood, 112, 1, 2008. Crossref
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Kirwan Sheryl E, Burshtyn Deborah N, Regulation of natural killer cell activity, Current Opinion in Immunology, 19, 1, 2007. Crossref
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Mewes Jacqueline, Verheijen Karlijn, Montgomery Benjamin C.S., Stafford James L., Stimulatory catfish leukocyte immune-type receptors (IpLITRs) demonstrate a unique ability to associate with adaptor signaling proteins and participate in the formation of homo- and heterodimers, Molecular Immunology, 47, 2-3, 2009. Crossref
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Schmitt Christian, Ghazi Bouchra, Bensussan Armand, NK cells and surveillance in humans, Reproductive BioMedicine Online, 16, 2, 2008. Crossref
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Sentman Charles L., Barber Melissa A., Barber Amorette, Zhang Tong, , 95, 2006. Crossref
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Zhou Gang, Juang Shih Wei W., Kane Kevin P., NK cells exacerbate the pathology of influenza virus infection in mice, European Journal of Immunology, 43, 4, 2013. Crossref
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Kveberg Lise, Sudworth Amanda, Todros-Dawda Izabela, Inngjerdingen Marit, Vaage John T., Functional characterization of a conserved pair of NKR-P1 receptors expressed by NK cells and T lymphocytes in liver and gut, European Journal of Immunology, 45, 2, 2015. Crossref
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Zhang Zhu-Xu, Huang Xuyan, Jiang Jifu, Lau Arthur, Yin Ziqin, Liu Weihua, Haig Aaron, Jevnikar Anthony M., Natural Killer Cells Mediate Long-term Kidney Allograft Injury, Transplantation, 99, 5, 2015. Crossref
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Okada Kazunari, Sato Shintaro, Sato Ayuko, Mandelboim Ofer, Yamasoba Tatsuya, Kiyono Hiroshi, Björkström Niklas K, Identification and Analysis of Natural Killer Cells in Murine Nasal Passages, PLOS ONE, 10, 11, 2015. Crossref
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Fišerová Anna, Richter Jan, Čapková Katarína, Bieblová Jana, Mikyšková Romana, Reiniš Milan, Indrová Marie, Resistance of novel mouse strains different in MHC class I and the NKC domain to the development of experimental tumors, International Journal of Oncology, 49, 2, 2016. Crossref
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Zhang Zhu-Xu, Wang Shuang, Huang Xuyan, Min Wei-Ping, Sun Hongtao, Liu Weihua, Garcia Bertha, Jevnikar Anthony M., NK Cells Induce Apoptosis in Tubular Epithelial Cells and Contribute to Renal Ischemia-Reperfusion Injury, The Journal of Immunology, 181, 11, 2008. Crossref
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Osman Mohammed S., Burshtyn Deborah N., Kane Kevin P., Activating Ly-49 Receptors Regulate LFA-1-Mediated Adhesion by NK Cells, The Journal of Immunology, 178, 3, 2007. Crossref
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Kielczewska Agnieszka, Kim Hee-Seo, Lanier Lewis L., Dimasi Nazzareno, Vidal Silvia M., Critical Residues at the Ly49 Natural Killer Receptor’s Homodimer Interface Determine Functional Recognition of m157, a Mouse Cytomegalovirus MHC Class I-Like Protein, The Journal of Immunology, 178, 1, 2007. Crossref
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Lavender Kerry J., Chau Heidi H., Kane Kevin P., Distinctive Interactions at Multiple Site 2 Subsites by Allele-Specific Rat and Mouse Ly49 Determine Functional Binding and Class I MHC Specificity, The Journal of Immunology, 179, 10, 2007. Crossref
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Corbett Alexandra J., Coudert Jerome D., Forbes Catherine A., Scalzo Anthony A., Functional Consequences of Natural Sequence Variation of Murine Cytomegalovirus m157 for Ly49 Receptor Specificity and NK Cell Activation, The Journal of Immunology, 186, 3, 2011. Crossref
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Lavender Kerry J., Kane Kevin P., Cross-Species Dependence of Ly49 Recognition on the Supertype Defining B-Pocket of a Class I MHC Molecule, The Journal of Immunology, 177, 12, 2006. Crossref
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Bláha Jan, Kalousková Barbora, Skořepa Ondřej, Pažický Samuel, Novák Petr, Vaněk Ondřej, High-level expression and purification of soluble form of human natural killer cell receptor NKR-P1 in HEK293S GnTI− cells, Protein Expression and Purification, 140, 2017. Crossref