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ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

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DOI: 10.1615/CritRevImmunol.v32.i4.30
pages 321-334

The Role of the Proto-Oncogene c-myc in B Lymphocyte Differentiation

David Fernandez
Department of Immunology and Oncology, National Center for Biotechnology CNB/CSIC, Madrid, Spain
Victor Javier Sanchez-Arevalo
Molecular Pathology Program, Epithelial Carcinogenesis Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
Ignacio Moreno de Alboran
Department of Immunology and Oncology, National Center for Biotechnology CNB/CSIC, Madrid, Spain

ABSTRACT

Since the discovery of the myc gene, few genes are likely to have such influence on biomedical research. The diversity of the biological functions regulated by this transcription factor and its impact in human health have attracted investigators from many different fields. The development of conditional knockout mouse models has allowed for the characterization of Myc-driven molecular mechanisms in primary cells in physiological and pathological conditions. In this review, we discuss some of the main functions and recent findings regarding c-Myc in in vivo B lymphocyte differentiation from early progenitors to terminally differentiated cells.


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