图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.v26.i3.30
pages 231-264

Human Cytomegalovirus Persists in Its Host and Attacks and Avoids Elimination by the Immune System

Cecilia Soderberg-Naucler
Department of Medicine, Center for Molecular Medicine, L8:03, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden

ABSTRACT

Human cytomegalovirus (HCMV) is a herpesvirus that infects, and is carried by, 70%−100% of the world's population. During its evolution, the virus has adapted to survive in an immunocompetent host. For many years, HCMV was not considered to be a major human pathogen because it only caused rare cases of HCMV inclusion disease in neonates. However, HCMV is poorly adapted to survive in the immunosuppressed host and has emerged as an important human pathogen in AIDS patients, and in patients undergoing immunosuppressive therapy after organ or bone marrow transplantation. The virus is also the major infectious cause of birth defects. To coexist with its host, HCMV must avoid elimination by the immune system. Research over the past decade has revealed sophisticated mechanisms that enable the virus to remain invisible to cells of the immune system.


Articles with similar content:

Long-Term Effects of Bone Morphogenetic Protein- Based Treatments in Humans
Journal of Long-Term Effects of Medical Implants, Vol.20, 2010, issue 4
Martin V. Burks, Lakshmi Nair
From Pattern Recognition Receptor to Regulator of Homeostasis: The Double-Faced Macrophage Mannose Receptor
Critical Reviews™ in Immunology, Vol.24, 2004, issue 3
Lorenzo Piemonti, Paola Allavena, Paolo Monti, Marcello Chieppa
Dynamics and Function of Solitary Intestinal Lymphoid Tissue
Critical Reviews™ in Immunology, Vol.28, 2008, issue 1
Gunter Bernhardt, Oliver Pabst, Heike Herbrand, Reinhold Forster
Sirtuins in Brain Aging and Neurological Disorders
Critical Reviews™ in Eukaryotic Gene Expression, Vol.27, 2017, issue 4
Muhammad Imran Qadir, Sidra Anwar
Expression and Immune Function of Tenascin-C
Critical Reviews™ in Immunology, Vol.31, 2011, issue 2
Irina A. Udalova, Kim S. Midwood, Scott J.P. Thomson, Michaela Ruhmann