图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.352 5年影响因子: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.2013006696
pages 97-118

Role of Diacylglycerol Kinases in T Cell Development and Function

Sruti Krishna
Department of Pediatrics, Division of Allergy and Immunology and Department of Immunology, Duke University Medical Center, Durham, NC
Xiaoping Zhong
Department of Pediatrics, Division of Allergy and Immunology and Department of Immunology, Duke University Medical Center, Durham, NC

ABSTRACT

Diacylglycerol (DAG), a second messenger generated by phospholipase Cγ1 activity upon engagement of a T-cell receptor, triggers several signaling cascades that play important roles in T cell development and function. A family of enzymes called DAG kinases (DGKs) catalyzes the phosphorylation of DAG to phosphatidic acid, acting as a braking mechanism that terminates DAG-mediated signals. Two DGK isoforms, α and ζ, are expressed predominantly in T cells and synergistically regulate the development of both conventional αβ T cells and invariant natural killer T cells in the thymus. In mature T cells, the activity of these DGK isoforms aids in the maintenance of self-tolerance by preventing T-cell hyperactivation upon T cell receptor stimulation and by promoting T-cell anergy. In CD8 cells, reduced DGK activity is associated with enhanced primary responses against viruses and tumors. Recent work also has established an important role for DGK activity at the immune synapse and identified partners that modulate DGK function. In addition, emerging evidence points to previously unappreciated roles for DGK function in directional secretion and T-cell adhesion. This review describes the multitude of roles played by DGKs in T cell development and function and emphasizes recent advances in the field.


Articles with similar content:

Modulation of the ATP-lnduced Release and Processing of IL-1β in Microglial Cells
Critical Reviews™ in Immunology, Vol.29, 2009, issue 4
Makoto Hashimoto, Yoshifumi Iwamaru, Hiroshi Kitani, Shuei Sugama, Takato Takenouchi
Regulation of Regulatory T Cells: Role of Dendritic Cells and Toll-Like Receptors
Critical Reviews™ in Immunology, Vol.26, 2006, issue 4
Dieter Kabelitz, Daniela Wesch, Hans-Heinrich Oberg
Inhibitory Receptor-Mediated Regulation of Natural Killer Cells
Critical Reviews™ in Immunology, Vol.34, 2014, issue 6
Beena Jeevan-Raj , Camille Grandclement, Werner Held, Elisenda Alari-Pahissa
Role of Type II NKT Cells in the Suppression of Graft-versus-Host Disease
Critical Reviews™ in Immunology, Vol.28, 2008, issue 3
Chang Ki Min, Ji Hyung Kim, Sae Jin Oh, Doo Hyun Chung
Regulation of NK Cell Repertoire and Function in the Liver
Critical Reviews™ in Immunology, Vol.31, 2011, issue 1
Peter D. Krueger, Huihong Qiao, Matthew G. Lassen, Young S. Hahn