每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
The Link between Psychological Stress and Autoimmune Response in Children
摘要
Stress is defined as a state of threatened homeostasis or disharmony that is counteracted by a complex repertoire of physiological and behavioral adaptive responses in order to establish homeostasis. Confronted with a stressful condition, the nervous and immune systems initiate a coping process to maintain homeostasis in the body. Psychological stress, recognized as a public health issue in children and young adults, may be one mechanism to induce and maintain autoimmunity in children. It is necessary to increase our understanding of how psychological stress can affect the immune system at a young age because autoimmune diseases, especially type 1 diabetes, are alarmingly common in children. Psychological stress may be involved in other autoimmune diseases, such as celiac disease, systemic lupus erythematosus, and juvenile idiopathic arthritis, that frequently occur in children as well. This review summarizes the studies attempting to evaluate the link between psychological stress and autoimmune response in children. A number of them have observed that the autoimmune disease itself causes psychological stress. We are far from fully understanding how long-term psychological stress is linked to autoimmune response in children with a high risk of, or already diagnosed, autoimmune disease.
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Braig Stefanie, Weiss Johannes M., Stalder Tobias, Kirschbaum Clemens, Rothenbacher Dietrich, Genuneit Jon, Maternal prenatal stress and child atopic dermatitis up to age 2 years: The Ulm SPATZ health study, Pediatric Allergy and Immunology, 28, 2, 2017. Crossref
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Wu Weizhong, Liu Sanguang, Liang Yunfei, Zhou Zegao, Bian Wei, Liu Xueqing, Stress Hormone Cortisol Enhances Bcl2 Like-12 Expression to Inhibit p53 in Hepatocellular Carcinoma Cells, Digestive Diseases and Sciences, 62, 12, 2017. Crossref
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Dadvand Payam, Poursafa Parinaz, Heshmat Ramin, Motlagh Mohammad Esmaeil, Qorbani Mostafa, Basagaña Xavier, Kelishadi Roya, Use of green spaces and blood glucose in children; a population-based CASPIAN-V study, Environmental Pollution, 243, 2018. Crossref
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Lundgren Markus, Ellström Katarina, Elding Larsson Helena, Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study, Acta Diabetologica, 55, 8, 2018. Crossref
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Kuvačić Goran, Fratini Patrizia, Padulo Johnny, Antonio Dello Iacono, De Giorgio Andrea, Effectiveness of yoga and educational intervention on disability, anxiety, depression, and pain in people with CLBP: A randomized controlled trial, Complementary Therapies in Clinical Practice, 31, 2018. Crossref
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Bansal Ciara Jade, Bansal Amolak Singh, Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria, Allergy, Asthma & Clinical Immunology, 15, 1, 2019. Crossref
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Logel Santhi N., Bekx M. Tracy, Rehm Jennifer L., Potential association between type 1 diabetes mellitus and gender dysphoria, Pediatric Diabetes, 21, 2, 2020. Crossref
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Roth Roswith, Lynch Kristian, Hyöty Heikki, Lönnrot Maria, Driscoll Kimberly A., Bennett Johnson Suzanne, The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study , Stress and Health, 35, 3, 2019. Crossref
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Dimitrijevic Carlsson Alexandra, Wahlund Kerstin, Kindgren Erik, Skogh Thomas, Starkhammar Johansson Carin, Alstergren Per, Orofacial pain in juvenile idiopathic arthritis is associated with stress as well as psychosocial and functional limitations, Pediatric Rheumatology, 17, 1, 2019. Crossref
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Bansal Rhea A., Bansal Amolak S., Exacerbating Factors in Chronic Spontaneous Urticaria, Current Treatment Options in Allergy, 7, 2, 2020. Crossref
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Ahmad Suhana, Al-Hatamleh Mohammad A.I., Mohamud Rohimah, Targeting immunosuppressor cells with nanoparticles in autoimmunity: How far have we come to?, Cellular Immunology, 368, 2021. Crossref
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Schiffenbauer Adam, Miller Frederick W., Noninfectious Environmental Agents and Autoimmunity, in The Autoimmune Diseases, 2020. Crossref
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Ortega Miguel A., García-Montero Cielo, Fraile-Martinez Oscar, Alvarez-Mon Miguel Angel, Gómez-Lahoz Ana Maria, Lahera Guillermo, Monserrat Jorge, Rodriguez-Jimenez Roberto, Quintero Javier, Álvarez-Mon Melchor, Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology, Biology, 11, 7, 2022. Crossref
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Bengtsson Jessica, Rieckmann Andreas, Carstensen Bendix, Svensson Jannet, Jørgensen Marit E., Rod Naja H., Trajectories of Childhood Adversity and Type 1 Diabetes: A Nationwide Study of One Million Children, Diabetes Care, 44, 3, 2021. Crossref
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Kawaguchi Chikana, Murakami Keiko, Ishikuro Mami, Ueno Fumihiko, Noda Aoi, Onuma Tomomi, Matsuzaki Fumiko, Metoki Hirohito, Kuriyama Shinichi, Obara Taku, Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study, BMC Pregnancy and Childbirth, 22, 1, 2022. Crossref
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Cunningham Katja, Mengelkoch Summer, Gassen Jeffrey, Hill Sarah E., Early life adversity, inflammation, and immune function: An initial test of adaptive response models of immunological programming, Development and Psychopathology, 34, 2, 2022. Crossref
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Kapfhammer Hans-Peter, Diabetes mellitus, in Depression, Angst, traumatischer Stress und internistische Erkrankungen, 2022. Crossref