图书馆订阅: Guest
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集
免疫学评论综述™
影响因子: 1.404 5年影响因子: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

免疫学评论综述™

DOI: 10.1615/CritRevImmunol.v16.i3.10
pages 223-250

Genes Responsible for Quantitative Regulation of Antibody Production

Anne Puel
Laboratoire d'lmmunogenetique, Unite INSERM 255, Institut Curie, 26, rue d'Ulm, 75231 PARIS CEDEX 05, FRANCE
Denise Mouton
Laboratoire d'lmmunogenetique, Unite INSERM 255, Institut Curie, 26, rue d'Ulm, 75231 PARIS CEDEX 05, FRANCE

ABSTRACT

Evidence is first presented demonstrating that the individual capacity for antibody responsiveness has an inheritable component. The main evidence consists of spontaneous mutations causing either immunodeficiency or predisposition to autoimmunity in human and animals, and the involvement of some obvious candidate genes (in particular those belonging to the highly polymorphic histocompatibility and Igh loci), extensively analyzed in many mouse strain combinations. One finding constantly emerging from these studies is that single gene expression depends on environmental effects, lowering the genotype/phenotype correlation, but also on multigenic interactions appearing as background effects. The models available for the analysis of this multigenic regulation are discussed with special emphasis on the high and low antibody responder mice produced for this purpose by bidirectional selective breeding. The major advantage of this model is that the interline difference is huge and multispecifically expressed. The second part of the review presents the recent results on positional mapping of genes with immunomodulatory effects in this model and in one appropriate recombinant congenic strain series. This in vivo genetic dissection of antibody responsiveness discriminated the involvement of candidate genes and suggested that unsuspected genes might be identified by means of this wide open search.


Articles with similar content:

The Role of the Leptin-Melanocortin Signalling Pathway in the Control of Food Intake
Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 4
Doreen Zegers, Sigri Beckers, Luc F. Van Gaal, Wim Van Hul
Functional Architecture of Chromosomal DNA Domains
Critical Reviews™ in Eukaryotic Gene Expression, Vol.6, 1996, issue 2-3
Sergey V. Razin
Tumor Protein D52 Overexpression and Gene Amplification in Cancers from a Mosaic of Microarrays
Critical Reviews™ in Oncogenesis, Vol.14, 2008, issue 1
Jayne R. Hardy, Jennifer A. Byrne, Judith Weidenhofer, Keerthi Thamotharampillai, Mona Shehata
Parameters of LRP5 from a Structural and Molecular Perspective
Critical Reviews™ in Eukaryotic Gene Expression, Vol.15, 2005, issue 3
Mark L. Johnson, Douglas T. Summerfield
Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia
Critical Reviews™ in Oncogenesis, Vol.16, 2011, issue 1-2
Mignon L. Loh, Sarah Tasian