每年出版 6 期
ISSN 打印: 1040-8401
ISSN 在线: 2162-6472
Indexed in
Pathogenesis of Multiple Organ Failure in Sepsis
摘要
Sepsis is a severe critical illness syndrome that arises from infectious insults. While the host immune system is generally beneficial, an overshooting and unregulated immune response can cause serious organ tissue injury. During sepsis, systemic hypotension, disturbed perfusion of the microcirculation, and direct tissue-toxicity caused by inflammatory immune reaction can occur and contribute to organ failure. The failure of two or more vital organ systems is termed multi-organ dysfunction syndrome (MODS) and resembles a very critical condition associated with high morbidity and mortality. Importantly, no specific treatment strategy exists to efficiently prevent the development of MODS during sepsis. In this review, we aim to identify the relevant molecular immunological pathways involved in the pathogenesis of MODS during sepsis. We believe that a detailed understanding of this mechanism is necessary for the development of new treatment approaches for septic patients. In particular, knowledge of the endogenous regulators keeping the balance between necessary immune system activation to combat infections and prevention of host tissue damage would greatly improve the chances for the development of effective interventions.
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GÜZEL Derya, TANYELİ Ayhan, DOĞANAY Songül, GÜLER Mustafa Can, ERASLAN Ersen, Urapidil Çekal Ligasyon ve Delme ile İndüklenen Akciğer ve Böbrek Hasarını Hafifletir, Sakarya Medical Journal, 2021. Crossref
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Zeng Yanping, Ma Weixing, ma Cheng, Ren Xiaohui, Wang Yan, Inhibition of TXNDC5 attenuates lipopolysaccharide-induced septic shock by altering inflammatory responses, Laboratory Investigation, 102, 4, 2022. Crossref
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Guerrero-Fonseca Idaira M., García-Ponce Alexander, Vadillo Eduardo, Lartey Nathaniel L., Vargas-Robles Hilda, Chánez-Paredes Sandra, Castellanos-Martínez Ramón, Nava Porfirio, Betanzos Abigail, Neumann Brittany M., Penkala-Auguste Kinga, Lefort Craig T., Schnoor Michael, HS1 deficiency protects against sepsis by attenuating neutrophil-inflicted lung damage, European Journal of Cell Biology, 101, 2, 2022. Crossref
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Daniel Matthieu, Bedoui Yosra, Vagner Damien, Raffray Loïc, Ah-Pine Franck, Doray Bérénice, Gasque Philippe, Pathophysiology of Sepsis and Genesis of Septic Shock: The Critical Role of Mesenchymal Stem Cells (MSCs), International Journal of Molecular Sciences, 23, 16, 2022. Crossref
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Quaglia Marco, Fanelli Vito, Merlotti Guido, Costamagna Andrea, Deregibus Maria Chiara, Marengo Marita, Balzani Eleonora, Brazzi Luca, Camussi Giovanni, Cantaluppi Vincenzo, Dual Role of Extracellular Vesicles in Sepsis-Associated Kidney and Lung Injury, Biomedicines, 10, 10, 2022. Crossref
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Wilden Anika, Glaubitz Juliane, Otto Oliver, Biedenweg Doreen, Nauck Matthias, Mack Matthias, Ribback Silvia, Bröker Barbara M., Rheinbaben Sabrina Freiin von, Lerch Markus M., Aghdassi Ali Alexander, Weiss Frank Ulrich, Sendler Matthias, Mobilization of CD11b+/Ly6chi monocytes causes multi organ dysfunction syndrome in acute pancreatitis, Frontiers in Immunology, 13, 2022. Crossref