图书馆订阅: Guest
免疫学评论综述™

每年出版 6 

ISSN 打印: 1040-8401

ISSN 在线: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Improving Immunotherapy by Conditionally Enhancing MHC Class I Presentation of Tumor Antigen-Derived Peptide Epitopes

卷 27, 册 5, 2007, pp. 485-493
DOI: 10.1615/CritRevImmunol.v27.i5.60
Get accessGet access

摘要

Tumors represent an “altered” self cell type that can be recognized by both the host humoral (B cells, antibodies) and cellular (T cells) adaptive immune systems. “Because most known tumor-associated antigens (TAA) recognized by T cells represent overexpressed or aberrantly expressed proteins, which are not mutated and to which tolerance has been developed, the anti−TAA T−cell repertoire available to the cancer patient is of moderate-to-low avidity. Specific vaccinations typically amplify the absolute number of such T cells, but may have little consequence on improving their functional avidity, which may fall below a critical threshold required for effective recognition of tumor cells in situ. This review will discuss methods to improve low-avidity T−cell recognition of cancer cells by manipulating the tumor cells themselves to conditionally express higher levels of TAA−derived peptide epitopes presented in major histocompatibility (MHC) complexes. This may facilitate the design and performance of novel combinational therapies for the effective treatment of a broad range of cancer types.

对本文的引用
  1. Gang Yi, Zhang Xiaoyin, He Yuanlong, Zheng Jianyong, Wu Kaichun, Ding Jie, Fan Daiming, Efficient induction of specific cytotoxic T lymphocytes against gastric adenocarcinoma by a survivin peptide, Biochemistry and Cell Biology, 90, 6, 2012. Crossref

  2. Tang Xu-Dong, Liang Guang-Ping, Li Chuan, Wan Ying, Chen Ting, Chen Ling, Yu Song-Tao, Xiong Zhen, Fang Dian-Chun, Wang Guo-Zheng, Yang Shi-Ming, Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice, Cancer Immunology, Immunotherapy, 59, 7, 2010. Crossref

  3. Riquelme Erick, Carreño Leandro J., González Pablo A., Kalergis Alexis M., The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity, European Journal of Immunology, 39, 8, 2009. Crossref

  4. Lee Byeong C., Jung Mi Y., Cho Daeho, O-Sullivan InSug, Cohen Edward P., Kim Tae Sung, Immunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice, Vaccine, 28, 49, 2010. Crossref

  5. Seliger Barbara, Dressler Sven P., Massa Chiara, Recktenwald Christian V., Altenberend Florian, Bukur Juergen, Marincola Francesco M., Wang Ena, Stevanovic Stefan, Lichtenfels Rudolf, Identification and characterization of human leukocyte antigen class I ligands in renal cell carcinoma cells, PROTEOMICS, 11, 12, 2011. Crossref

  6. Fecek Ronald J., Raveendran Subhara, Chelvanambi Manoj, Storkus Walter J., Inhibition of HSPs for Enhanced Immunity, in Heat Shock Proteins in the Immune System, 2018. Crossref

  7. Kawabe Mayumi, Herrem Christopher J., Finke James H., Storkus Walter J., EphA2: A Novel Target in Renal Cell Carcinoma, in Renal Cell Carcinoma, 2009. Crossref

  8. Zhang Song, Zeng Cheng, Wang Dong, Gao Xiaobo, Guo Shun, Zhang Yan, Shi Lei, Efficient induction of cytotoxic T lymphocytes in hepatocellular carcinoma using the HLA-A2-restricted survivin peptide in vitro, Experimental Cell Research, 386, 2, 2020. Crossref

  9. Kawabe Mayumi, Mandic Maja, Taylor Jennifer L., Vasquez Cecilia A., Wesa Amy K., Neckers Leonard M., Storkus Walter J., Heat Shock Protein 90 Inhibitor 17-Dimethylaminoethylamino-17-Demethoxygeldanamycin Enhances EphA2+ Tumor Cell Recognition by Specific CD8+ T Cells, Cancer Research, 69, 17, 2009. Crossref

将发表的论文

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell 数字图书馆 电子图书 期刊 参考文献及会议录 研究收集 订购及政策 Begell House 联系我们 Language English 中文 Русский Português German French Spain