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ISSN 打印: 1040-8401
ISSN 在线: 2162-6472

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DOI: 10.1615/CritRevImmunol.v21.i1-3.70
18 pages

The Potential of CpG Oligodeoxynucleotides as Mucosal Adjuvants

Risini D. Weeratna
Coley Pharmaceutical Group, Ottawa
Paul J. Payette
Coley Pharmaceutical Group, Ottawa; Loeb Health Research Institute, Ottawa; Faculties of Health Sciences and Medicine, University of Ottawa
Heather L. Davis
Coley Pharmaceutical Group, Ottawa; Loeb Health Research Institute, Ottawa; Faculties of Health Sciences and Medicine, University of Ottawa

ABSTRACT

The development of mucosal vaccines for humans has been hindered by the lack of safe yet effective mucosal adjuvants. Bacterial toxins are commonly used as adjuvants in animal models, but they are too toxic for use in humans. A novel class of adjuvant is CpG DNA, which contains unmethylated CpG dinucleotides in particular base contexts (CpG motifs). CpG DNA is most often coadministered with antigen in the form of synthetic oligodeoxynucleotides (CpG ODN), which are made with a nuclease-resistant phosphorothioate backbone. The vast majority of studies using CpG DNA as adjuvant have been with parenteral delivery; recently, however, mucosal immunization with CpG DNA as adjuvant has also been shown to induce both systemic (humoral and cellular) and mucosal antigen-specific immune responses. This review will highlight the recent uses of CpG DNA as an adjuvant at mucosal surfaces.


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